Introduction: To evaluate the effect of different chelating agents on the wettability of AH Plus and BioRoot RCS sealers on intraradicular dentin. Materials and Methods: Fifty single-rooted premolars were split longitudinally and divided into five groups according to irrigant regimen. Group 1: 2.5% sodium hypochlorite (NaOCl)-17% ethylenediaminetetraacetic acid (EDTA); Group 2: 2.5% NaOCl-7% maleic acid (MA); Group 3: 2.5% NaOCl-SmearOFF™ (containing chlorhexidine and EDTA); Group 4: 2.5% NaOCl-Dual Rinse® hydroxyethylidene diphosphonic acid (HEDP); Group 5: 2.5% NaOCl-distilled water. Specimens were treated with controlled volume of experimental sealers and subjected to contact angle measurement. Results: Wettability of both sealers on intraradicular dentin was found to be best with MA. For AH Plus sealer, wettability was better with SmearOFF™, followed by EDTA, Dual Rinse® HEDP, and distilled water. However, there was no statistical difference between SmearOFF™ and EDTA (P > 0.05). For BioRoot RCS, wettability was better with SmearOFF™ and EDTA, with the former showing better results (P < 0.001). This was followed by Dual Rinse® HEDP and distilled water. Conclusion: Within the limitations of the study, it can be concluded that MA when used as a final irrigant showed better wettability of both AH Plus and BioRoot RCS sealers compared to the other tested solutions.
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