Effect of ciprofloxacin and sodium valproate on chemical induced seizures in mice: An acute study

To evaluate the effect of ciprofloxacin & ciprofloxacin with sodium valproate in PTZ induced seizures in mice. The animals were divided into 4 groups and each group consists of 6 animals. The first group received normal saline, the second received ciprofloxacin, the third received sodium valproate and the fourth group received ciprofloxacin 30minutes prior to sodium valproate. After 45 minutes, Pentylenetetrazole given to all the groups & animals were observed for next one hour for generalised tonic clonic seizures. The data was analysed using SPSS software & results were interpreted by comparing different groups using Students't' test. The P value of ≤0.05 considered to be statistically significant. Ciprofloxacin significantly decreased the onset & increased the duration of generalized tonic clonic seizures. When given in presence of sodium valproate, ciprofloxacin significantly decreased the onset of jerk, straub tail & generalized tonic clonic seizures while there was significant increase in the duration of generalized tonic clonic seizures. Ciprofloxacin decreases the threshold for seizures in predisposed mice, has proconvulsant effect & also diminishes the anti epileptic effect of sodium valproate.