Effect of clobetasol propionate and clobetasol butyrate with biopolymer on skin inflammatory model in wistar rats

K. L. Bairy, A. V. Pawan kumar, B. R. Chandrashekar, Avinash M. Holla, Rockson Christopher, Purnima Sirigiri, M. C. Satish Kumar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The treatment of chronic inflammatory skin conditions are not satisfactory. There is a need for better antiflammatory drugs for these conditions. This study was done to compare the efficacy of biopolymer based formulations of clobetasol propionate and clobetasol butyrate with commercially available Preparations of clobetasol in animal models of superficial skininflammation in rats. The croton oil ear edema in rats was the chronic inflammatory model used in this study. In this model, the animals treated with clobetasol propionate and clobetasol butyrate with biopolymer showed a significant decrease in inflammation as compared to commercially available preparations of clobetasol(Tenovate and Eumosone).

Original languageEnglish
Pages (from-to)66-68
Number of pages3
JournalJournal of Applied Pharmaceutical Science
Volume2
Issue number2
Publication statusPublished - 01-02-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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