Effect of conventional and LED phototherapy on the antioxidant-oxidant status in preterm neonates with jaundice

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Abstract

Objective: To compare oxidative stress due to conventional and LED phototherapy among jaundiced preterm neonates. Methods: Cross-sectional study conducted in NICU on 82 neonates (equal numbers received conventional and LED phototherapy). Total antioxidant capacity (TAC), total oxidant status (TOS) and Oxidative stress index (OSI) were assessed. Results: Post-phototherapy, mean (SD) OSI increased significantly compared to baseline in both conventional [0.26 (0.24) vs. 0.61 (0.41); P <0.001] and LED groups [0.24 (0.20) vs. 0.32 (0.23); P <0.001]. Across groups, mean (SD) TAC was lower [0.28 (0.16) vs. 0.53 (0.27); P <0.001] mmol Trolox equiv/L; mean (SD) TOS higher [15.6 (10.9) vs. 14.6 (10.2); P=0.711] μmol H2O2/L and mean (SD) OSI higher [0.61 (0.42) vs. 0.33 (0.23); P <0.001] in conventional as compared to LED phototherapy. Conclusion: Both modes increased oxidative stress index; however, conventional phototherapy resulted in higher oxidative stress.

Original languageEnglish
Pages (from-to)644-646
Number of pages3
JournalIndian Pediatrics
Volume54
Issue number8
DOIs
Publication statusPublished - 01-08-2017

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Phototherapy
Jaundice
Oxidants
Oxidative Stress
Antioxidants
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{9a2e581a07d748648781597217b52367,
title = "Effect of conventional and LED phototherapy on the antioxidant-oxidant status in preterm neonates with jaundice",
abstract = "Objective: To compare oxidative stress due to conventional and LED phototherapy among jaundiced preterm neonates. Methods: Cross-sectional study conducted in NICU on 82 neonates (equal numbers received conventional and LED phototherapy). Total antioxidant capacity (TAC), total oxidant status (TOS) and Oxidative stress index (OSI) were assessed. Results: Post-phototherapy, mean (SD) OSI increased significantly compared to baseline in both conventional [0.26 (0.24) vs. 0.61 (0.41); P <0.001] and LED groups [0.24 (0.20) vs. 0.32 (0.23); P <0.001]. Across groups, mean (SD) TAC was lower [0.28 (0.16) vs. 0.53 (0.27); P <0.001] mmol Trolox equiv/L; mean (SD) TOS higher [15.6 (10.9) vs. 14.6 (10.2); P=0.711] μmol H2O2/L and mean (SD) OSI higher [0.61 (0.42) vs. 0.33 (0.23); P <0.001] in conventional as compared to LED phototherapy. Conclusion: Both modes increased oxidative stress index; however, conventional phototherapy resulted in higher oxidative stress.",
author = "Anusha Allam and Ravikiran, {S. R.} and Baliga, {B. Shantaram} and Kamalakshi Bhat and Nitin Joseph",
year = "2017",
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doi = "10.1007/s13312-017-1127-x",
language = "English",
volume = "54",
pages = "644--646",
journal = "Indian Pediatrics",
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TY - JOUR

T1 - Effect of conventional and LED phototherapy on the antioxidant-oxidant status in preterm neonates with jaundice

AU - Allam, Anusha

AU - Ravikiran, S. R.

AU - Baliga, B. Shantaram

AU - Bhat, Kamalakshi

AU - Joseph, Nitin

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Objective: To compare oxidative stress due to conventional and LED phototherapy among jaundiced preterm neonates. Methods: Cross-sectional study conducted in NICU on 82 neonates (equal numbers received conventional and LED phototherapy). Total antioxidant capacity (TAC), total oxidant status (TOS) and Oxidative stress index (OSI) were assessed. Results: Post-phototherapy, mean (SD) OSI increased significantly compared to baseline in both conventional [0.26 (0.24) vs. 0.61 (0.41); P <0.001] and LED groups [0.24 (0.20) vs. 0.32 (0.23); P <0.001]. Across groups, mean (SD) TAC was lower [0.28 (0.16) vs. 0.53 (0.27); P <0.001] mmol Trolox equiv/L; mean (SD) TOS higher [15.6 (10.9) vs. 14.6 (10.2); P=0.711] μmol H2O2/L and mean (SD) OSI higher [0.61 (0.42) vs. 0.33 (0.23); P <0.001] in conventional as compared to LED phototherapy. Conclusion: Both modes increased oxidative stress index; however, conventional phototherapy resulted in higher oxidative stress.

AB - Objective: To compare oxidative stress due to conventional and LED phototherapy among jaundiced preterm neonates. Methods: Cross-sectional study conducted in NICU on 82 neonates (equal numbers received conventional and LED phototherapy). Total antioxidant capacity (TAC), total oxidant status (TOS) and Oxidative stress index (OSI) were assessed. Results: Post-phototherapy, mean (SD) OSI increased significantly compared to baseline in both conventional [0.26 (0.24) vs. 0.61 (0.41); P <0.001] and LED groups [0.24 (0.20) vs. 0.32 (0.23); P <0.001]. Across groups, mean (SD) TAC was lower [0.28 (0.16) vs. 0.53 (0.27); P <0.001] mmol Trolox equiv/L; mean (SD) TOS higher [15.6 (10.9) vs. 14.6 (10.2); P=0.711] μmol H2O2/L and mean (SD) OSI higher [0.61 (0.42) vs. 0.33 (0.23); P <0.001] in conventional as compared to LED phototherapy. Conclusion: Both modes increased oxidative stress index; however, conventional phototherapy resulted in higher oxidative stress.

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