Effect of conventional and LED phototherapy on the antioxidant-oxidant status in preterm neonates with jaundice

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Objective: To compare oxidative stress due to conventional and LED phototherapy among jaundiced preterm neonates. Methods: Cross-sectional study conducted in NICU on 82 neonates (equal numbers received conventional and LED phototherapy). Total antioxidant capacity (TAC), total oxidant status (TOS) and Oxidative stress index (OSI) were assessed. Results: Post-phototherapy, mean (SD) OSI increased significantly compared to baseline in both conventional [0.26 (0.24) vs. 0.61 (0.41); P <0.001] and LED groups [0.24 (0.20) vs. 0.32 (0.23); P <0.001]. Across groups, mean (SD) TAC was lower [0.28 (0.16) vs. 0.53 (0.27); P <0.001] mmol Trolox equiv/L; mean (SD) TOS higher [15.6 (10.9) vs. 14.6 (10.2); P=0.711] μmol H2O2/L and mean (SD) OSI higher [0.61 (0.42) vs. 0.33 (0.23); P <0.001] in conventional as compared to LED phototherapy. Conclusion: Both modes increased oxidative stress index; however, conventional phototherapy resulted in higher oxidative stress.

Original languageEnglish
Pages (from-to)644-646
Number of pages3
JournalIndian Pediatrics
Issue number8
Publication statusPublished - 01-08-2017


All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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