Effect of crystallinity on absorption and excretion patterns of ibuprofen, tinidazole and lorazepam

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Abstract

Various physical forms of Ibuprofen, Tinidazole and Lorazepam were prepared. Different crystal forms of these drugs were characterized with the help of Differential Scanning Calorimetry X-ray diffrection patterns, I.R. spectra and micro photographs of samples. The dissolution and diffusion rates of physical forms were determined. The absorption pattern of drug by insitu rat intestine was also studied using Doluisio technique. After oral administration cumulative amount of drug excreted in urine was determined.

Original languageEnglish
Pages (from-to)2749-2769
Number of pages21
JournalDrug Development and Industrial Pharmacy
Volume13
Issue number15
DOIs
Publication statusPublished - 1987

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Tinidazole
Lorazepam
Ibuprofen
Pharmaceutical Preparations
Differential Scanning Calorimetry
Intestines
Oral Administration
Rats
Differential scanning calorimetry
Dissolution
X-Rays
Urine
X rays
Crystals

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry
  • Molecular Medicine

Cite this

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abstract = "Various physical forms of Ibuprofen, Tinidazole and Lorazepam were prepared. Different crystal forms of these drugs were characterized with the help of Differential Scanning Calorimetry X-ray diffrection patterns, I.R. spectra and micro photographs of samples. The dissolution and diffusion rates of physical forms were determined. The absorption pattern of drug by insitu rat intestine was also studied using Doluisio technique. After oral administration cumulative amount of drug excreted in urine was determined.",
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