Effect of curcumin analogues on oxidation of haemoglobin and lysis of erythrocytes

P. Venkatesan, M.K. Unnikrishnan, M. Sudheer Kumar, M.N.A. Rao

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A number of ring-substituted analogues of curcumin were studied for their ability to prevent nitrite-induced oxidation of haemoglobin and lysis of erythrocytes. Phenolic analogues were more active than their non-phenolic counterparts. Many of the active compounds were more potent than standard antioxidants such as tocopherol and trolox. Tetrahydrocurcumin showed higher activity than curcumin, suggesting that unsaturation in the central portion of curcumin may not be important for activity.
Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalCurrent Science
Volume84
Issue number1
Publication statusPublished - 2003

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lysis
hemoglobin
antioxidant
nitrite
oxidation
effect

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Venkatesan, P., Unnikrishnan, M. K., Sudheer Kumar, M., & Rao, M. N. A. (2003). Effect of curcumin analogues on oxidation of haemoglobin and lysis of erythrocytes. Current Science, 84(1), 74-78.
Venkatesan, P. ; Unnikrishnan, M.K. ; Sudheer Kumar, M. ; Rao, M.N.A. / Effect of curcumin analogues on oxidation of haemoglobin and lysis of erythrocytes. In: Current Science. 2003 ; Vol. 84, No. 1. pp. 74-78.
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Venkatesan, P, Unnikrishnan, MK, Sudheer Kumar, M & Rao, MNA 2003, 'Effect of curcumin analogues on oxidation of haemoglobin and lysis of erythrocytes', Current Science, vol. 84, no. 1, pp. 74-78.

Effect of curcumin analogues on oxidation of haemoglobin and lysis of erythrocytes. / Venkatesan, P.; Unnikrishnan, M.K.; Sudheer Kumar, M.; Rao, M.N.A.

In: Current Science, Vol. 84, No. 1, 2003, p. 74-78.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of curcumin analogues on oxidation of haemoglobin and lysis of erythrocytes

AU - Venkatesan, P.

AU - Unnikrishnan, M.K.

AU - Sudheer Kumar, M.

AU - Rao, M.N.A.

N1 - Cited By :11 Export Date: 10 November 2017 CODEN: CUSCA Correspondence Address: Venkatesan, P.; Divi's Laboratories Ltd., C-26, Industrial Estate, Sanath Nagar, Hyderabad 500 018, India; email: pvenkat2373@yahoo.com References: Noguchi, N., Komuo, E., Niki, E., Willson, R.L., (1994) Yukagaku Zasshi, 43, pp. 1045-1051; Sreejayan, Rao, M.N.A., (1996) Arzneimittelforschung, 46, pp. 838-843; Srimal, R.C., (1997) Fitoterpia, 68, pp. 483-492; Perchellet, J.P., Perchllet, E.M., (1989) Free Radic. Biol. Med., 7, pp. 377-408; Mukundan, M.A., Chacko, M.C., Annapurna, V.V., Krishnaswami, K., (1993) Carcinogenesis, 14, pp. 493-496; Ruby, A.J., Kuttan, G., Dinesh Babu, K.V., Rajasekharan, Kuttan, R., (1998) Pharm. Pharmacol. Commun., 4, pp. 103-106; Sharma, O.P., (1976) Biochem. Pharmacol., 25, pp. 1811-1812; Tonnessen, H.H., Greenhill, J.V., (1992) Int. J. Pharm., 87, pp. 79-87; Conney, A.H., Lysz, T., Ferraro, T., Abidi, T.F., Manchand, P.S., Laskin, J.D., Haung, M.T., (1990) Adv. Enzyme Regul., 31, pp. 385-396; Venkatesan, P., Rao, M.N.A., (2000) J. Pharm. Pharmacol., 52, pp. 1123-1128; Hilmy, A.M., El-Domiaty, N.A., Weshana, K., (1987) Biochem. Physiol. C, 86, pp. 247-253; Bath, R.N., Eddy, F.B., (1980) J. Exp. Zool., 214, pp. 119-121; Kosoka, H., Tyuma, I., (1987) Environ. Health Prespect., 73, pp. 147-151; Unnikrishnan, M.K., Rao, M.N.A., (1992) FEBS Lett., 301, pp. 195-196; Pabon, H.J.J., (1964) Recl. Trav. Chim. Pays-Bas, 83, pp. 379-386; Nakayama, T., Ono, K., Hashimoto, K., (1998) Biosci. Biotechnol. Biochem., 62, pp. 1005-1007; Goodford, P.J., (1977) Drug Action at Molecular Level, pp. 109-126. , (ed. Robert, G. C. K.), University Park Press, London; Akio, K., Yoshimasa, T., Toshihiko, O., US Patent 5266344, 1990; Sugiyama, Y., Kawakishi, S., Osawa, T., (1996) Biochem. Pharmacol., 52, pp. 519-525; Khopde, S.M., Priyadarsini, K.I., Guha, S.N., Satav, J.G., Venkatesan, P., Rao, M.N.A., (2000) Biosci. Biotechnol. Biochem., 64, pp. 503-509; Gumuslu, S., Serteser, M., Aydin, M., Yucel, G., (1997) J. Basic Clin. Physiol. Pharmacol., 8, pp. 45-56; Toda, S., Ohnishi, M., Kimura, M., Nakashima, K., (1988) J. Ethnopharmacol., 23, pp. 105-108; Tonnessen, H.H., Kristensen, S., Grinberg, L.N., (1994) Int. J. Pharm., 110, pp. 161-167; Kleszezynska, H., Sarapuk, J., (1998) Biochem. Mol. Biol. Int., 46, pp. 385-390; Urano, S., (1992), 267, pp. 18365-18370; Osawa, T., Sugiyama, Y., Inayoshi, M., Kawakishi, S., (1995) Biosci. Biotechnol. Biochem., 59, pp. 1609-1612; Haung, M.T., (1995) Carcinogenesis, 16, pp. 2493-2497; Kim, J.H., (1998) Carcinogenesis, 19, pp. 81-85

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Venkatesan P, Unnikrishnan MK, Sudheer Kumar M, Rao MNA. Effect of curcumin analogues on oxidation of haemoglobin and lysis of erythrocytes. Current Science. 2003;84(1):74-78.