Effect of different statins in animal model of anxiety in wistar rats

V. C. Jyothsna, O. Balaji, Bharti Chogtu

Research output: Contribution to journalArticle

Abstract

Objective: Pleiotropic mechanisms of statins have been explored in treating neurological disorders such as generalized anxiety disorder and depression. Hence, the aim of the present study is to evaluate the effect of different statins in animal model of anxiety in Wistar rats. Methods: Sixty rats were divided into five groups of 6 rats each for each model. Two models were used, elevated plus maze and open-field model. Grouping is as follows: Group 1-normal control (0.9% saline), Group 2-alprazolam 0.5 mg/kg, Group 3-atorvastatin 10 mg/kg, Group 4-rosuvastatin 10 mg/kg, and Group 5-pitavastatin 10 mg/kg. All drugs were given orally for 30 days. Results: In open-field model and in elevated plus maze, alprazolam, atorvastatin, rosuvastatin, and pitavastatin in comparison with control showed significant antianxiety effect (p<0.01 and p<0.001), respectively. Conclusion: Hence, further clinical trials can be done to see the effect of various statins on generalized anxiety disorder in comparison with standard antianxiety drugs.

Original languageEnglish
Pages (from-to)369-371
Number of pages3
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume11
Issue number10
DOIs
Publication statusPublished - 01-10-2018

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Alprazolam
Wistar Rats
Anxiety
Animal Models
Anxiety Disorders
Anti-Anxiety Agents
Nervous System Diseases
Pharmaceutical Preparations
Clinical Trials
Depression
Atorvastatin Calcium
pitavastatin
Rosuvastatin Calcium

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

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abstract = "Objective: Pleiotropic mechanisms of statins have been explored in treating neurological disorders such as generalized anxiety disorder and depression. Hence, the aim of the present study is to evaluate the effect of different statins in animal model of anxiety in Wistar rats. Methods: Sixty rats were divided into five groups of 6 rats each for each model. Two models were used, elevated plus maze and open-field model. Grouping is as follows: Group 1-normal control (0.9{\%} saline), Group 2-alprazolam 0.5 mg/kg, Group 3-atorvastatin 10 mg/kg, Group 4-rosuvastatin 10 mg/kg, and Group 5-pitavastatin 10 mg/kg. All drugs were given orally for 30 days. Results: In open-field model and in elevated plus maze, alprazolam, atorvastatin, rosuvastatin, and pitavastatin in comparison with control showed significant antianxiety effect (p<0.01 and p<0.001), respectively. Conclusion: Hence, further clinical trials can be done to see the effect of various statins on generalized anxiety disorder in comparison with standard antianxiety drugs.",
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Effect of different statins in animal model of anxiety in wistar rats. / Jyothsna, V. C.; Balaji, O.; Chogtu, Bharti.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, No. 10, 01.10.2018, p. 369-371.

Research output: Contribution to journalArticle

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