Effect of drugs used in pulmonary edema (frusemide and combination of etofylline and theophylline) on surfactant system of lung.

G. J. Rao, A. R. Aroor, K. Nalini, A. K. Rao

Research output: Contribution to journalArticle

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Abstract

Pulmonary surfactant activity of healthy male albino rats was estimated in terms of the maximum and minimum surface tension values of alveolar washings and the phospholipid content of the extract. The results obtained in these (control) animals were compared with those in two groups of animals treated with therapeutic doses of frusemide and a combination of etofylline and theophylline. A significant increase in surfactant activity in terms of surface tension values and phospholipid content was observed with frusemide, whereas a significant increase in phospholipid content without a change in surface tension values was observed in the case of combination of etofylline and theophylline. These findings suggest that frusemide in addition to its diuretic action, increases the surfactant activity of lung. This might be another mechanism by which it provides relief in pulmonary edema patients. The study also indicates that phospholipid concentration need not always reflect surfactant activity of lung.

Original languageEnglish
Pages (from-to)59-62
Number of pages4
JournalThe Indian journal of chest diseases & allied sciences
Volume33
Issue number2
Publication statusPublished - 01-04-1991

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Furosemide
Pulmonary Edema
Theophylline
Surface-Active Agents
Surface Tension
Phospholipids
Lung
Pharmaceutical Preparations
Pulmonary Surfactants
Diuretics
etofylline
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Pulmonary surfactant activity of healthy male albino rats was estimated in terms of the maximum and minimum surface tension values of alveolar washings and the phospholipid content of the extract. The results obtained in these (control) animals were compared with those in two groups of animals treated with therapeutic doses of frusemide and a combination of etofylline and theophylline. A significant increase in surfactant activity in terms of surface tension values and phospholipid content was observed with frusemide, whereas a significant increase in phospholipid content without a change in surface tension values was observed in the case of combination of etofylline and theophylline. These findings suggest that frusemide in addition to its diuretic action, increases the surfactant activity of lung. This might be another mechanism by which it provides relief in pulmonary edema patients. The study also indicates that phospholipid concentration need not always reflect surfactant activity of lung.",
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Effect of drugs used in pulmonary edema (frusemide and combination of etofylline and theophylline) on surfactant system of lung. / Rao, G. J.; Aroor, A. R.; Nalini, K.; Rao, A. K.

In: The Indian journal of chest diseases & allied sciences, Vol. 33, No. 2, 01.04.1991, p. 59-62.

Research output: Contribution to journalArticle

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AU - Rao, G. J.

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AB - Pulmonary surfactant activity of healthy male albino rats was estimated in terms of the maximum and minimum surface tension values of alveolar washings and the phospholipid content of the extract. The results obtained in these (control) animals were compared with those in two groups of animals treated with therapeutic doses of frusemide and a combination of etofylline and theophylline. A significant increase in surfactant activity in terms of surface tension values and phospholipid content was observed with frusemide, whereas a significant increase in phospholipid content without a change in surface tension values was observed in the case of combination of etofylline and theophylline. These findings suggest that frusemide in addition to its diuretic action, increases the surfactant activity of lung. This might be another mechanism by which it provides relief in pulmonary edema patients. The study also indicates that phospholipid concentration need not always reflect surfactant activity of lung.

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