Effect of ethanolic leaf extract of Ocimum sanctum on haloperidol-induced catalepsy in albino mice

S. Pemminati, V. Nair, P. Dorababu, H. N. Gopalakrishna, M. R.S.M. Pai

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Neuroleptic drugs used in the treatment of schizophrenia and other affective disorders are known to produce extrapyramidal side effects. Catalepsy induced by these drugs in animals has been used as a model for the extrapyramidal side effects associated with antipsychotic agents in human beings. In the present study, we have attempted to evaluate the protective effect of the ethanolic leaf extractof Ocimum sanctum (OS) on haloperidol (1.0 mg/kg, intraperitoneal administration)-induced catalepsy in mice by employing the standard bar test. Mice were allocated to seven groups, each group containing six animals. The effects of the test drug OS (at 1.75, 4.25 and 8.5 mg/kg doses) and the standard drugs, scopolamine (1.0 mg/kg) and ondansetron (0.5 and 1.0 mg/kg doses) were assessed after single and repeat dose administration for seven days, 30 minutes prior to the haloperidol. The results suggest that OS has a protective effect against haloperidol-induced catalepsy, which is comparable to the standard drugs used for the same purpose. Our study indicates that OS could be used to prevent drug-induced extrapyramidal side effects.

Original languageEnglish
Pages (from-to)87-89
Number of pages3
JournalIndian Journal of Pharmacology
Volume39
Issue number2
Publication statusPublished - 01-03-2007
Externally publishedYes

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Catalepsy
Haloperidol
Pharmaceutical Preparations
Antipsychotic Agents
Ondansetron
Scopolamine Hydrobromide
Mood Disorders
Schizophrenia
Ocimum sanctum

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Pemminati, S., Nair, V., Dorababu, P., Gopalakrishna, H. N., & Pai, M. R. S. M. (2007). Effect of ethanolic leaf extract of Ocimum sanctum on haloperidol-induced catalepsy in albino mice. Indian Journal of Pharmacology, 39(2), 87-89.
Pemminati, S. ; Nair, V. ; Dorababu, P. ; Gopalakrishna, H. N. ; Pai, M. R.S.M. / Effect of ethanolic leaf extract of Ocimum sanctum on haloperidol-induced catalepsy in albino mice. In: Indian Journal of Pharmacology. 2007 ; Vol. 39, No. 2. pp. 87-89.
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Pemminati, S, Nair, V, Dorababu, P, Gopalakrishna, HN & Pai, MRSM 2007, 'Effect of ethanolic leaf extract of Ocimum sanctum on haloperidol-induced catalepsy in albino mice', Indian Journal of Pharmacology, vol. 39, no. 2, pp. 87-89.

Effect of ethanolic leaf extract of Ocimum sanctum on haloperidol-induced catalepsy in albino mice. / Pemminati, S.; Nair, V.; Dorababu, P.; Gopalakrishna, H. N.; Pai, M. R.S.M.

In: Indian Journal of Pharmacology, Vol. 39, No. 2, 01.03.2007, p. 87-89.

Research output: Contribution to journalArticle

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Pemminati S, Nair V, Dorababu P, Gopalakrishna HN, Pai MRSM. Effect of ethanolic leaf extract of Ocimum sanctum on haloperidol-induced catalepsy in albino mice. Indian Journal of Pharmacology. 2007 Mar 1;39(2):87-89.