Effect of exposure to hydrogen peroxide on the virulence of Escherichia coli

A. Hegde, G. Bhat, S. Mallya

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: To eliminate pathogenic bacteria, the host presents conditions that are stressful for bacteria. Oxidative stress arises when the concentration of pro-oxidants like hydrogen peroxide (H2O2 ) and superoxide anion increases to a level over the basal defence capacity of the cell. In the present study, we studied the effect of oxidative stress on the production of certain virulence factors by Escherichia coli. Methods: E. coli was exposed to oxidative stress by growing in the presence of different concentrations of H2O2. The effect of oxidative stress on the expression of surface hydrophobicity, adherence, haemolysin production, serum resistance and phagocytosis was studied. Results: Oxidative stress caused a significant decrease in the expression of all the virulence factors of E. coli. Conclusions: Synthesis of virulence factors can be significantly altered by oxidative stress and such changes may affect the pathogenicity of E. coli.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalIndian Journal of Medical Microbiology
Volume26
Issue number1
Publication statusPublished - 01-01-2008

Fingerprint

Hydrogen Peroxide
Virulence
Oxidative Stress
Escherichia coli
Virulence Factors
Bacteria
Hemolysin Proteins
Hydrophobic and Hydrophilic Interactions
Phagocytosis
Superoxides
Reactive Oxygen Species
Serum

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

@article{aefbc259399b4b8ca4f2548e8704f131,
title = "Effect of exposure to hydrogen peroxide on the virulence of Escherichia coli",
abstract = "Purpose: To eliminate pathogenic bacteria, the host presents conditions that are stressful for bacteria. Oxidative stress arises when the concentration of pro-oxidants like hydrogen peroxide (H2O2 ) and superoxide anion increases to a level over the basal defence capacity of the cell. In the present study, we studied the effect of oxidative stress on the production of certain virulence factors by Escherichia coli. Methods: E. coli was exposed to oxidative stress by growing in the presence of different concentrations of H2O2. The effect of oxidative stress on the expression of surface hydrophobicity, adherence, haemolysin production, serum resistance and phagocytosis was studied. Results: Oxidative stress caused a significant decrease in the expression of all the virulence factors of E. coli. Conclusions: Synthesis of virulence factors can be significantly altered by oxidative stress and such changes may affect the pathogenicity of E. coli.",
author = "A. Hegde and G. Bhat and S. Mallya",
year = "2008",
month = "1",
day = "1",
language = "English",
volume = "26",
pages = "25--28",
journal = "Indian Journal of Medical Microbiology",
issn = "0255-0857",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",

}

Effect of exposure to hydrogen peroxide on the virulence of Escherichia coli. / Hegde, A.; Bhat, G.; Mallya, S.

In: Indian Journal of Medical Microbiology, Vol. 26, No. 1, 01.01.2008, p. 25-28.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of exposure to hydrogen peroxide on the virulence of Escherichia coli

AU - Hegde, A.

AU - Bhat, G.

AU - Mallya, S.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Purpose: To eliminate pathogenic bacteria, the host presents conditions that are stressful for bacteria. Oxidative stress arises when the concentration of pro-oxidants like hydrogen peroxide (H2O2 ) and superoxide anion increases to a level over the basal defence capacity of the cell. In the present study, we studied the effect of oxidative stress on the production of certain virulence factors by Escherichia coli. Methods: E. coli was exposed to oxidative stress by growing in the presence of different concentrations of H2O2. The effect of oxidative stress on the expression of surface hydrophobicity, adherence, haemolysin production, serum resistance and phagocytosis was studied. Results: Oxidative stress caused a significant decrease in the expression of all the virulence factors of E. coli. Conclusions: Synthesis of virulence factors can be significantly altered by oxidative stress and such changes may affect the pathogenicity of E. coli.

AB - Purpose: To eliminate pathogenic bacteria, the host presents conditions that are stressful for bacteria. Oxidative stress arises when the concentration of pro-oxidants like hydrogen peroxide (H2O2 ) and superoxide anion increases to a level over the basal defence capacity of the cell. In the present study, we studied the effect of oxidative stress on the production of certain virulence factors by Escherichia coli. Methods: E. coli was exposed to oxidative stress by growing in the presence of different concentrations of H2O2. The effect of oxidative stress on the expression of surface hydrophobicity, adherence, haemolysin production, serum resistance and phagocytosis was studied. Results: Oxidative stress caused a significant decrease in the expression of all the virulence factors of E. coli. Conclusions: Synthesis of virulence factors can be significantly altered by oxidative stress and such changes may affect the pathogenicity of E. coli.

UR - http://www.scopus.com/inward/record.url?scp=38849157860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38849157860&partnerID=8YFLogxK

M3 - Article

C2 - 18227593

AN - SCOPUS:38849157860

VL - 26

SP - 25

EP - 28

JO - Indian Journal of Medical Microbiology

JF - Indian Journal of Medical Microbiology

SN - 0255-0857

IS - 1

ER -