Effect of exposure to low-dose gamma radiation during late organogenesis in the mouse fetus

P. U. Devi, R. Baskar, M. P. Hande

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The abdominal region of pregnant Swiss mice was exposed to 0.05 to 0.50 Gy of γ radiation on day 11.5 postcoitus. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, changes in head size and brain weight, and incidence of microphthalmia. No marked increase in fetal mortality or growth retardation was observed below 0.25 Gy; the increase in these parameters was significant only at 0.50 Gy. A significant reduction in head size and brain weight and a significant increase in the incidence of microphthalmia were observed at doses above 0.15 Gy. Detectable levels of microcephaly and microphthalmia were evident even at 0.10 Gy. A linear dose response was seen for these effects in the dose range of 0.05 to 0.15 Gy. It is concluded that the late period of organogenesis in the mouse, especially between days 10 and 12 postcoitus, is a particularly sensitive phase in the development of the skull, brain and eye.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalRadiation Research
Volume138
Issue number1
DOIs
Publication statusPublished - 01-01-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

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