Effect of extract of Benincasa hispida on oxidative stress in rats with indomethacin induced gastric ulcers

Beena V. Shetty, Albina Arjuman, Aparna Jorapur, Rajashree Samanth, Sudhir Kumar Yadav, N. Valliammai, Anna Deepthy Tharian, K. Sudha, Gayathri M. Rao

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This study was undertaken to determine the healing of ulcers induced by indomethacin due to antioxidant role of fruit extract of Benincasa hispida (Ashgourd) on ulcers in rats. Malondialdehyde (MDA) in RBC and antral homogenate was determined to measure tissue oxidation. Superoxide dismutase (SOD) in RBC and antral homogenate, plasma and homogenate vitamin C were estimated as measures of antioxidant defense. On induction of gastric ulcer, there was significant increase in SOD in RBC and homogenate levels and vitamin C in plasma. There was an apparent decrease in ulcer index in animals treated with fruit extract. There was significant decrease in MDA with concomitant decrease in SOD and vitamin C levels in the treated rats when compared to those not treated with fruit extract. Benincasa hispida has been shown to contain certain active principles like terpenes, flavanoid C - glycosides and sterols which have antioxidant effects. These probably inhibit gastric mucosal injury by scavenging the free radicals and repress production of SOD and vitamin C in these rats.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalIndian Journal of Physiology and Pharmacology
Volume52
Issue number2
Publication statusPublished - 01-04-2008

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Stomach Ulcer
Indomethacin
Ascorbic Acid
Superoxide Dismutase
Oxidative Stress
Ulcer
Fruit
Antioxidants
Malondialdehyde
Terpenes
Sterols
Free Radicals
Stomach
Wounds and Injuries
Antral

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Shetty, Beena V. ; Arjuman, Albina ; Jorapur, Aparna ; Samanth, Rajashree ; Yadav, Sudhir Kumar ; Valliammai, N. ; Tharian, Anna Deepthy ; Sudha, K. ; Rao, Gayathri M. / Effect of extract of Benincasa hispida on oxidative stress in rats with indomethacin induced gastric ulcers. In: Indian Journal of Physiology and Pharmacology. 2008 ; Vol. 52, No. 2. pp. 178-182.
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Effect of extract of Benincasa hispida on oxidative stress in rats with indomethacin induced gastric ulcers. / Shetty, Beena V.; Arjuman, Albina; Jorapur, Aparna; Samanth, Rajashree; Yadav, Sudhir Kumar; Valliammai, N.; Tharian, Anna Deepthy; Sudha, K.; Rao, Gayathri M.

In: Indian Journal of Physiology and Pharmacology, Vol. 52, No. 2, 01.04.2008, p. 178-182.

Research output: Contribution to journalArticle

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AU - Shetty, Beena V.

AU - Arjuman, Albina

AU - Jorapur, Aparna

AU - Samanth, Rajashree

AU - Yadav, Sudhir Kumar

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AU - Rao, Gayathri M.

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N2 - This study was undertaken to determine the healing of ulcers induced by indomethacin due to antioxidant role of fruit extract of Benincasa hispida (Ashgourd) on ulcers in rats. Malondialdehyde (MDA) in RBC and antral homogenate was determined to measure tissue oxidation. Superoxide dismutase (SOD) in RBC and antral homogenate, plasma and homogenate vitamin C were estimated as measures of antioxidant defense. On induction of gastric ulcer, there was significant increase in SOD in RBC and homogenate levels and vitamin C in plasma. There was an apparent decrease in ulcer index in animals treated with fruit extract. There was significant decrease in MDA with concomitant decrease in SOD and vitamin C levels in the treated rats when compared to those not treated with fruit extract. Benincasa hispida has been shown to contain certain active principles like terpenes, flavanoid C - glycosides and sterols which have antioxidant effects. These probably inhibit gastric mucosal injury by scavenging the free radicals and repress production of SOD and vitamin C in these rats.

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