Effect of fetal exposure to ultrasound on the behavior of the adult mouse

P. U. Devi, R. Suresh, M. P. Hande

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Pregnant Swiss albino mice were exposed to diagnostic ultrasound (3.5 MHz, 65 mW, I(SPTP) = 1 W/cm2, I(SATA) = 240 W/cm2) for 10, 20 or 30 min on day 14.5 (fetal period) of gestation. Sham-exposed controls were studied for comparison. Any changes in physiological reflexes (such as pinna detachment, opening of the eyes and development of fur), postnatal mortality and changes in adult behavior (open-field test, dark/bright arena test, hole board test and conditioned-avoidance test) were recorded. No change was observed in the physiological reflexes. The postnatal survival was also not affected significantly by the exposure. However, there were significant alterations in behavior in all three exposed groups as revealed by the decreased locomotor and exploratory activity and the increase in the number of trials needed for learning. These results indicate that ultrasound exposure during the early fetal period can impair brain function in the adult mouse.

Original languageEnglish
Pages (from-to)314-317
Number of pages4
JournalRadiation Research
Volume141
Issue number3
DOIs
Publication statusPublished - 06-03-1995
Externally publishedYes

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mice
Reflex
reflexes
Locomotion
Ultrasonography
mortality
avoidance
field tests
Learning
detachment
Pregnancy
learning
brain
Mortality
Brain
N-hydroxysuccinimide S-acetylthioacetate

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

Devi, P. U. ; Suresh, R. ; Hande, M. P. / Effect of fetal exposure to ultrasound on the behavior of the adult mouse. In: Radiation Research. 1995 ; Vol. 141, No. 3. pp. 314-317.
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Effect of fetal exposure to ultrasound on the behavior of the adult mouse. / Devi, P. U.; Suresh, R.; Hande, M. P.

In: Radiation Research, Vol. 141, No. 3, 06.03.1995, p. 314-317.

Research output: Contribution to journalArticle

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AU - Suresh, R.

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