Effect of fucithalmic and sofinox eye drops on experimental allergic conjunctivitis in rats

Shakta Mani Satyam, Shalini Adiga, Bharti Chogtu, K. Laxminarayana Bairy, Rajadurai Pirasanthan, Rajdip Lalit Vaishnav

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate the therapeutic effect of Fucithalmic 1%, Sofinox 0.5% and 1% eye drops against an IgE-mediated allergic conjunctivitis model in Wistar rats.

Methods: IgE-mediated allergic conjunctivitis was induced by ovalbumin antigen challenge. Allergic conjunctivitis induced control rats (Group I) received normal saline (0.9% NaCl; 10 μl/eye) whereas Fucithalmic 1% (Group II), Sofinox 0.5% (Group III) and 1% (Group IV) were administered as 10, 20 and 10 μl/eye respectively to the treatment group animals (n=6) for 15 days. Eye scratching behavior, hypothermia and edema was evaluated after topical antigen challenge.

Results: Sofinox 1% eye drops (10 μl/eye) significantly attenuated eye scratching behavior, hyperemia and edema in comparison with allergic conjunctivitis induced control (p < 0.001) and Fucithalmic 1% treated rats (p < 0.05). Eye scratching behavior and edema was also significantly decreased in Sofinox 0.5% eye drops (20 μl/eye) treatment group as compared to allergic conjunctivitis induced control rats (p < 0.05).

Conclusion: The present study revealed that the Sofinox eye drop is the potential agent that could offer a novel therapeutic opportunity against IgE-mediated allergic conjunctivitis in Wistar rats.

Original languageEnglish
Pages (from-to)458-460
Number of pages3
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume6
Issue number11
Publication statusPublished - 2014

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Fusidic Acid
Allergic Conjunctivitis
Ophthalmic Solutions
Immunoglobulin E
Edema
Wistar Rats
Antigens
Hyperemia
Ovalbumin
Therapeutic Uses
Hypothermia
Control Groups

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

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title = "Effect of fucithalmic and sofinox eye drops on experimental allergic conjunctivitis in rats",
abstract = "Objective: To investigate the therapeutic effect of Fucithalmic 1{\%}, Sofinox 0.5{\%} and 1{\%} eye drops against an IgE-mediated allergic conjunctivitis model in Wistar rats.Methods: IgE-mediated allergic conjunctivitis was induced by ovalbumin antigen challenge. Allergic conjunctivitis induced control rats (Group I) received normal saline (0.9{\%} NaCl; 10 μl/eye) whereas Fucithalmic 1{\%} (Group II), Sofinox 0.5{\%} (Group III) and 1{\%} (Group IV) were administered as 10, 20 and 10 μl/eye respectively to the treatment group animals (n=6) for 15 days. Eye scratching behavior, hypothermia and edema was evaluated after topical antigen challenge.Results: Sofinox 1{\%} eye drops (10 μl/eye) significantly attenuated eye scratching behavior, hyperemia and edema in comparison with allergic conjunctivitis induced control (p < 0.001) and Fucithalmic 1{\%} treated rats (p < 0.05). Eye scratching behavior and edema was also significantly decreased in Sofinox 0.5{\%} eye drops (20 μl/eye) treatment group as compared to allergic conjunctivitis induced control rats (p < 0.05).Conclusion: The present study revealed that the Sofinox eye drop is the potential agent that could offer a novel therapeutic opportunity against IgE-mediated allergic conjunctivitis in Wistar rats.",
author = "Satyam, {Shakta Mani} and Shalini Adiga and Bharti Chogtu and {Laxminarayana Bairy}, K. and Rajadurai Pirasanthan and Vaishnav, {Rajdip Lalit}",
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Effect of fucithalmic and sofinox eye drops on experimental allergic conjunctivitis in rats. / Satyam, Shakta Mani; Adiga, Shalini; Chogtu, Bharti; Laxminarayana Bairy, K.; Pirasanthan, Rajadurai; Vaishnav, Rajdip Lalit.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, No. 11, 2014, p. 458-460.

Research output: Contribution to journalArticle

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T1 - Effect of fucithalmic and sofinox eye drops on experimental allergic conjunctivitis in rats

AU - Satyam, Shakta Mani

AU - Adiga, Shalini

AU - Chogtu, Bharti

AU - Laxminarayana Bairy, K.

AU - Pirasanthan, Rajadurai

AU - Vaishnav, Rajdip Lalit

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AB - Objective: To investigate the therapeutic effect of Fucithalmic 1%, Sofinox 0.5% and 1% eye drops against an IgE-mediated allergic conjunctivitis model in Wistar rats.Methods: IgE-mediated allergic conjunctivitis was induced by ovalbumin antigen challenge. Allergic conjunctivitis induced control rats (Group I) received normal saline (0.9% NaCl; 10 μl/eye) whereas Fucithalmic 1% (Group II), Sofinox 0.5% (Group III) and 1% (Group IV) were administered as 10, 20 and 10 μl/eye respectively to the treatment group animals (n=6) for 15 days. Eye scratching behavior, hypothermia and edema was evaluated after topical antigen challenge.Results: Sofinox 1% eye drops (10 μl/eye) significantly attenuated eye scratching behavior, hyperemia and edema in comparison with allergic conjunctivitis induced control (p < 0.001) and Fucithalmic 1% treated rats (p < 0.05). Eye scratching behavior and edema was also significantly decreased in Sofinox 0.5% eye drops (20 μl/eye) treatment group as compared to allergic conjunctivitis induced control rats (p < 0.05).Conclusion: The present study revealed that the Sofinox eye drop is the potential agent that could offer a novel therapeutic opportunity against IgE-mediated allergic conjunctivitis in Wistar rats.

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