The aqueous extract of the bark showed a significant hypoglycaemic effect and hepatic enzymes lowering effect. However, ability of Helicteres isora bark on gluconeogenic and glycolytic enzymes in diabetes has not been studied yet. Present investigation has been carried out to study the regulation of carbohydrate metabolic and catabolic such as hexokinase, aldolase and phosphoglucoisomerase, and gluconeogenic enzymes such as glucose-6-phosphatase and fructose -1,6-diphosphatase in liver and kidneys of normal and streptozotocin induced diabetic rats. There were a decrease in the activities of glucose-6-phosphatase, fructose-1, 6-disphosphatase, aldolase and an increase in the activity of phosphoglucoisomerase and hexokinase in tissues. Helicteres isora extract exhibited antidiabetic activity by enhancing the peripheral utilization of glucose by correcting liver and kidney glycolysis and by limiting its gluconeogenic formation similar to insulin.
|Number of pages||4|
|Publication status||Published - 2008|
Sharma, A., Vijayakumar, M., Verma, A. R., Unnikrishnan, M. K., Singh, M., & Rao, C. V. (2008). Effect of helicteres isora root extract on gluconeogenic and glycolytic enzymes in streptozotocin-induced diabetic rats. Biomedicine, 28(4), 298-301.