Effect of intraoperative infusion of dexmedetomidine on emergence agitation among adults undergoing nasal surgeries-a prospective randomised double blind study

B. K. Deepak, Malavika Kulkarni, M. M. Sumanth, Muralidhar M. Kulkarni

Research output: Contribution to journalArticle

Abstract

Context: Emergence agitation (EA) is significant in patients recovering from general anaesthesia for nasal surgery. Aim: To assess the efficacy of dexmedetomidine infusion in reducing the incidence of EA in adults undergoing nasal surgery. Settings and Design: In this prospective randomised double blind study we recruited 56 adult patients belonging to ASA 1& 2 and aged 18-60 years. Methods and Material: Group D [n=28] received a continuous infusion of dexmedetomidine at 0.4 μg/kg/hr from induction of anaesthesia until nasal packing. Group C [n=28] received a volume matched infusion of 0.9% saline. Incidence of EA was diagnosed on a score of 5 or more on the Ricker sedation agitation scale. Haemodynamic parameters, time of awakening and post-operative recovery characteristics in the perioperative period were also observed. Statistical analysis was performed using independent samples T-test, Chi-Square test or Fisher’s Exact test. Results: The incidence of EA was significantly lesser with 11(39.3%) subjects in Group D compared to 24(85.7%) subjects in Group C (p < 0.01). The mean duration of time of awakening was prolonged in group D compared to group C (11.14 min vs 5.43 min). The heart rate and mean arterial pressure were significantly lower in the study group compared to the control group (p value<0.01). The number of patients requiring rescue fentanyl in study group compared to control in Post Anaesthesia Care Unit (1 Vs 18) was significantly less. Conclusion: Dexmedetomidine infusion during nasal surgery satisfactorily reduces the incidence of EA without increasing the adverse effects.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalMiddle East Journal of Anesthesiology
Volume25
Issue number1
Publication statusPublished - 01-02-2018

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Nasal Surgical Procedures
Dexmedetomidine
Double-Blind Method
Incidence
Anesthesia
Perioperative Period
Fentanyl
Chi-Square Distribution
Nose
General Anesthesia
Arterial Pressure
Heart Rate
Hemodynamics
Emergence Delirium
Control Groups

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

@article{1bfb41e0ed5a45c4b534e53a7e8010ea,
title = "Effect of intraoperative infusion of dexmedetomidine on emergence agitation among adults undergoing nasal surgeries-a prospective randomised double blind study",
abstract = "Context: Emergence agitation (EA) is significant in patients recovering from general anaesthesia for nasal surgery. Aim: To assess the efficacy of dexmedetomidine infusion in reducing the incidence of EA in adults undergoing nasal surgery. Settings and Design: In this prospective randomised double blind study we recruited 56 adult patients belonging to ASA 1& 2 and aged 18-60 years. Methods and Material: Group D [n=28] received a continuous infusion of dexmedetomidine at 0.4 μg/kg/hr from induction of anaesthesia until nasal packing. Group C [n=28] received a volume matched infusion of 0.9{\%} saline. Incidence of EA was diagnosed on a score of 5 or more on the Ricker sedation agitation scale. Haemodynamic parameters, time of awakening and post-operative recovery characteristics in the perioperative period were also observed. Statistical analysis was performed using independent samples T-test, Chi-Square test or Fisher’s Exact test. Results: The incidence of EA was significantly lesser with 11(39.3{\%}) subjects in Group D compared to 24(85.7{\%}) subjects in Group C (p < 0.01). The mean duration of time of awakening was prolonged in group D compared to group C (11.14 min vs 5.43 min). The heart rate and mean arterial pressure were significantly lower in the study group compared to the control group (p value<0.01). The number of patients requiring rescue fentanyl in study group compared to control in Post Anaesthesia Care Unit (1 Vs 18) was significantly less. Conclusion: Dexmedetomidine infusion during nasal surgery satisfactorily reduces the incidence of EA without increasing the adverse effects.",
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Effect of intraoperative infusion of dexmedetomidine on emergence agitation among adults undergoing nasal surgeries-a prospective randomised double blind study. / Deepak, B. K.; Kulkarni, Malavika; Sumanth, M. M.; Kulkarni, Muralidhar M.

In: Middle East Journal of Anesthesiology, Vol. 25, No. 1, 01.02.2018, p. 95-101.

Research output: Contribution to journalArticle

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AU - Deepak, B. K.

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AU - Sumanth, M. M.

AU - Kulkarni, Muralidhar M.

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N2 - Context: Emergence agitation (EA) is significant in patients recovering from general anaesthesia for nasal surgery. Aim: To assess the efficacy of dexmedetomidine infusion in reducing the incidence of EA in adults undergoing nasal surgery. Settings and Design: In this prospective randomised double blind study we recruited 56 adult patients belonging to ASA 1& 2 and aged 18-60 years. Methods and Material: Group D [n=28] received a continuous infusion of dexmedetomidine at 0.4 μg/kg/hr from induction of anaesthesia until nasal packing. Group C [n=28] received a volume matched infusion of 0.9% saline. Incidence of EA was diagnosed on a score of 5 or more on the Ricker sedation agitation scale. Haemodynamic parameters, time of awakening and post-operative recovery characteristics in the perioperative period were also observed. Statistical analysis was performed using independent samples T-test, Chi-Square test or Fisher’s Exact test. Results: The incidence of EA was significantly lesser with 11(39.3%) subjects in Group D compared to 24(85.7%) subjects in Group C (p < 0.01). The mean duration of time of awakening was prolonged in group D compared to group C (11.14 min vs 5.43 min). The heart rate and mean arterial pressure were significantly lower in the study group compared to the control group (p value<0.01). The number of patients requiring rescue fentanyl in study group compared to control in Post Anaesthesia Care Unit (1 Vs 18) was significantly less. Conclusion: Dexmedetomidine infusion during nasal surgery satisfactorily reduces the incidence of EA without increasing the adverse effects.

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