Effect of intravenous dexmedetomidine on spinal anaesthesia with hyperbaric bupivacaine in lower limb orthopedic surgeries - A randomized controlled study

Adithya Jayaprakash, Shaik Gulam Osmani, Y. Anupama Suresh, Y. V. Suresh

Research output: Contribution to journalArticle

Abstract

Introduction: Alpha-2 adrenoceptor agonists such as Clonidine, dexmedetomidine both have analgesic and sedative properties when used intravenous. Unsatisfactory regional anesthesia necessitates supplementary intravenous analgesia and deep sedation to relive anxiety AIM: To observe the effect of intravenous dexmedetomidine in spinal anaesthesia with respect to sensory block, motor block, depth of sedation and the time to first analgesic requirement in lower limb orthopedic surgeries. Materials and Method: 60 consenting patients undergoing lower limb orthopaedic surgeries were selected. Dexmedetomidine group (D) received a loading dose of 0.5 mcg/kg dexmedetomidine over 10 mins before spinal anaesthesia followed by an infusion of 0.5 mcg /kg/hr till the end of surgery. Control group ‘C’ received similar volume of normal saline infusion. The parameters observed were the highest sensory level achieved, time to two segment regression, duration of motor block and time to first requirement of analgesia. Ramsay score was used to assess sedation and hemodynamic parameters noted. Results: The maximum sensory level achieved was higher in group ‘D’ than in group ‘C’. The time to two segment regression, The duration of motor block and The time to first requirement of analgesia was prolong in dexmedetomidine then in control group. Also the sedation score were higher in group ‘D’. Conclusion: I.V. Dexmedetomidine as an adjuvant in spinal anaesthesia prolongs the duration of both sensory and motor blockade and also delays the time to rescue analgesia, thus eliminating the need to use multiple drugs for sedation and analgesia.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalIndian Journal of Public Health Research and Development
Volume9
Issue number12
DOIs
Publication statusPublished - 01-12-2018

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Dexmedetomidine
Spinal Anesthesia
Bupivacaine
Orthopedics
Lower Extremity
Analgesia
Analgesics
Deep Sedation
Control Groups
Conduction Anesthesia
Clonidine
Hypnotics and Sedatives
Adrenergic Receptors
Anxiety
Hemodynamics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

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title = "Effect of intravenous dexmedetomidine on spinal anaesthesia with hyperbaric bupivacaine in lower limb orthopedic surgeries - A randomized controlled study",
abstract = "Introduction: Alpha-2 adrenoceptor agonists such as Clonidine, dexmedetomidine both have analgesic and sedative properties when used intravenous. Unsatisfactory regional anesthesia necessitates supplementary intravenous analgesia and deep sedation to relive anxiety AIM: To observe the effect of intravenous dexmedetomidine in spinal anaesthesia with respect to sensory block, motor block, depth of sedation and the time to first analgesic requirement in lower limb orthopedic surgeries. Materials and Method: 60 consenting patients undergoing lower limb orthopaedic surgeries were selected. Dexmedetomidine group (D) received a loading dose of 0.5 mcg/kg dexmedetomidine over 10 mins before spinal anaesthesia followed by an infusion of 0.5 mcg /kg/hr till the end of surgery. Control group ‘C’ received similar volume of normal saline infusion. The parameters observed were the highest sensory level achieved, time to two segment regression, duration of motor block and time to first requirement of analgesia. Ramsay score was used to assess sedation and hemodynamic parameters noted. Results: The maximum sensory level achieved was higher in group ‘D’ than in group ‘C’. The time to two segment regression, The duration of motor block and The time to first requirement of analgesia was prolong in dexmedetomidine then in control group. Also the sedation score were higher in group ‘D’. Conclusion: I.V. Dexmedetomidine as an adjuvant in spinal anaesthesia prolongs the duration of both sensory and motor blockade and also delays the time to rescue analgesia, thus eliminating the need to use multiple drugs for sedation and analgesia.",
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Effect of intravenous dexmedetomidine on spinal anaesthesia with hyperbaric bupivacaine in lower limb orthopedic surgeries - A randomized controlled study. / Jayaprakash, Adithya; Osmani, Shaik Gulam; Anupama Suresh, Y.; Suresh, Y. V.

In: Indian Journal of Public Health Research and Development, Vol. 9, No. 12, 01.12.2018, p. 311-316.

Research output: Contribution to journalArticle

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AU - Jayaprakash, Adithya

AU - Osmani, Shaik Gulam

AU - Anupama Suresh, Y.

AU - Suresh, Y. V.

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N2 - Introduction: Alpha-2 adrenoceptor agonists such as Clonidine, dexmedetomidine both have analgesic and sedative properties when used intravenous. Unsatisfactory regional anesthesia necessitates supplementary intravenous analgesia and deep sedation to relive anxiety AIM: To observe the effect of intravenous dexmedetomidine in spinal anaesthesia with respect to sensory block, motor block, depth of sedation and the time to first analgesic requirement in lower limb orthopedic surgeries. Materials and Method: 60 consenting patients undergoing lower limb orthopaedic surgeries were selected. Dexmedetomidine group (D) received a loading dose of 0.5 mcg/kg dexmedetomidine over 10 mins before spinal anaesthesia followed by an infusion of 0.5 mcg /kg/hr till the end of surgery. Control group ‘C’ received similar volume of normal saline infusion. The parameters observed were the highest sensory level achieved, time to two segment regression, duration of motor block and time to first requirement of analgesia. Ramsay score was used to assess sedation and hemodynamic parameters noted. Results: The maximum sensory level achieved was higher in group ‘D’ than in group ‘C’. The time to two segment regression, The duration of motor block and The time to first requirement of analgesia was prolong in dexmedetomidine then in control group. Also the sedation score were higher in group ‘D’. Conclusion: I.V. Dexmedetomidine as an adjuvant in spinal anaesthesia prolongs the duration of both sensory and motor blockade and also delays the time to rescue analgesia, thus eliminating the need to use multiple drugs for sedation and analgesia.

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