Effect of irradiation at the early foetal stage on adult brain function of mouse

Learning and memory

M. Hossain, P. Uma Devi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: To study the long-term effect of early foetal irradiation on the learning and memory in the adult mouse. Materials and methods: The abdominal area of pregnant Swiss albino mice was exposed to a single dose of 0.25-1.5 Gy γ-radiation on the 14th day of gestation and the mice were left to deliver their offspring. At 6 months of age, the learning and memory functions of the F1 mice were tested by hole-board activity, conditioned avoidance response and radial arm maze performance. The animals were again subjected to the radial arm maze test at 12 and 18 months of age. Results: There was a significant dose-dependent decrease in the learning ability and memory retention of 6-month-old mice at doses >0.25 Gy. The significant changes persisted to 18 months of age in mice exposed to ≥0.5 Gy. All changes showed a linear dose-response at doses <1 Gy. Conclusions: The gestational day 14 of Swiss albino mice is a sensitive stage in brain development to γ-ray-induced impairment of learning and memory during the adult life. Permanent deficits in these functions can be induced by a dose of ∼0.5 Gy at this stage, when the developmental activity of the cerebral cortex is at its peak.

Original languageEnglish
Pages (from-to)581-585
Number of pages5
JournalInternational Journal of Radiation Biology
Volume77
Issue number5
DOIs
Publication statusPublished - 24-05-2001
Externally publishedYes

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Learning
Brain
Radiation Dosage
Aptitude
Cerebral Cortex
Pregnancy

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Effect of irradiation at the early foetal stage on adult brain function of mouse: Learning and memory",
abstract = "Purpose: To study the long-term effect of early foetal irradiation on the learning and memory in the adult mouse. Materials and methods: The abdominal area of pregnant Swiss albino mice was exposed to a single dose of 0.25-1.5 Gy γ-radiation on the 14th day of gestation and the mice were left to deliver their offspring. At 6 months of age, the learning and memory functions of the F1 mice were tested by hole-board activity, conditioned avoidance response and radial arm maze performance. The animals were again subjected to the radial arm maze test at 12 and 18 months of age. Results: There was a significant dose-dependent decrease in the learning ability and memory retention of 6-month-old mice at doses >0.25 Gy. The significant changes persisted to 18 months of age in mice exposed to ≥0.5 Gy. All changes showed a linear dose-response at doses <1 Gy. Conclusions: The gestational day 14 of Swiss albino mice is a sensitive stage in brain development to γ-ray-induced impairment of learning and memory during the adult life. Permanent deficits in these functions can be induced by a dose of ∼0.5 Gy at this stage, when the developmental activity of the cerebral cortex is at its peak.",
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Effect of irradiation at the early foetal stage on adult brain function of mouse : Learning and memory. / Hossain, M.; Uma Devi, P.

In: International Journal of Radiation Biology, Vol. 77, No. 5, 24.05.2001, p. 581-585.

Research output: Contribution to journalArticle

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