Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers

Thittamaranahalli Muguregowda Honnegowda, Pramod Kumar, Padmanabha Udupa, Pragna Rao, Siddhartha Bhandary, Krishna Kumar Mahato, Anurag Sharan, Shreemathi S. Mayya

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Background: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue. Materials and Method: A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (n = 17) and conventional dressing group (n = 17). Results: Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (P = 0.026), total protein (P = 0.004), GPx level (P = 0.030) and GST level (P = 0.045). Conclusion: Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.

Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalIndian Journal of Plastic Surgery
Issue number2
Publication statusPublished - 2014


All Science Journal Classification (ASJC) codes

  • Surgery

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