Effect of low intensity helium-neon (He-Ne) laser irradiation on diabetic wound healing dynamics

G. Arun Maiya, Pramod Kumar, Laxmi Rao

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine the effect of low-energy He-Ne laser treatment on wound healing dynamics (histological and biochemical) in diabetic rats. Background data: Low-energy laser photostimulation at certain wavelengths can enhance tissue repair by releasing growth factors from fibroblasts and can facilitate the healing process of diabetic wounds. Materials and methods: A circular 4 cm2 excisional wound was created on the dorsum of the experimentally (Alloxan)-induced diabetic rats. In the study group (N = 24) the wound was treated with He-Ne laser (632.8 nm wavelength) at a dose of 4.8 J/cm2 for 5 days a week until the wound healed completely. The control group (N = 24) was sham-irradiated. The results were statistically analyzed by an independent t test for biochemical analysis and the nonparametric Mann-Whitney U test for histopathological parameters. Results: The analysis of the biochemical parameters and histopathological parameters of the wounds showed that the laser-treated group healed faster and better as compared to the control group (p < 0.0001). The laser-treated group healed on average by the 18th day whereas, the control group healed on average by the 59th day. Conclusion: Laser photostimulation promotes the tissue repair process of diabetic wounds.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalPhotomedicine and Laser Surgery
Volume23
Issue number2
DOIs
Publication statusPublished - 01-04-2005

Fingerprint

Helium neon lasers
Neon
Gas Lasers
Laser beam effects
Wound Healing
Lasers
Wounds and Injuries
Rats
Repair
Tissue
Wavelength
Control Groups
Fibroblasts
Dosimetry
Alloxan
Fibroblast Growth Factors
Nonparametric Statistics

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

@article{8b4bc5dc061a448d8df8d9f0804f0559,
title = "Effect of low intensity helium-neon (He-Ne) laser irradiation on diabetic wound healing dynamics",
abstract = "Objective: The aim of this study was to determine the effect of low-energy He-Ne laser treatment on wound healing dynamics (histological and biochemical) in diabetic rats. Background data: Low-energy laser photostimulation at certain wavelengths can enhance tissue repair by releasing growth factors from fibroblasts and can facilitate the healing process of diabetic wounds. Materials and methods: A circular 4 cm2 excisional wound was created on the dorsum of the experimentally (Alloxan)-induced diabetic rats. In the study group (N = 24) the wound was treated with He-Ne laser (632.8 nm wavelength) at a dose of 4.8 J/cm2 for 5 days a week until the wound healed completely. The control group (N = 24) was sham-irradiated. The results were statistically analyzed by an independent t test for biochemical analysis and the nonparametric Mann-Whitney U test for histopathological parameters. Results: The analysis of the biochemical parameters and histopathological parameters of the wounds showed that the laser-treated group healed faster and better as compared to the control group (p < 0.0001). The laser-treated group healed on average by the 18th day whereas, the control group healed on average by the 59th day. Conclusion: Laser photostimulation promotes the tissue repair process of diabetic wounds.",
author = "Maiya, {G. Arun} and Pramod Kumar and Laxmi Rao",
year = "2005",
month = "4",
day = "1",
doi = "10.1089/pho.2005.23.187",
language = "English",
volume = "23",
pages = "187--190",
journal = "Photomedicine and Laser Surgery",
issn = "1549-5418",
publisher = "Mary Ann Liebert Inc.",
number = "2",

}

Effect of low intensity helium-neon (He-Ne) laser irradiation on diabetic wound healing dynamics. / Maiya, G. Arun; Kumar, Pramod; Rao, Laxmi.

In: Photomedicine and Laser Surgery, Vol. 23, No. 2, 01.04.2005, p. 187-190.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of low intensity helium-neon (He-Ne) laser irradiation on diabetic wound healing dynamics

AU - Maiya, G. Arun

AU - Kumar, Pramod

AU - Rao, Laxmi

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Objective: The aim of this study was to determine the effect of low-energy He-Ne laser treatment on wound healing dynamics (histological and biochemical) in diabetic rats. Background data: Low-energy laser photostimulation at certain wavelengths can enhance tissue repair by releasing growth factors from fibroblasts and can facilitate the healing process of diabetic wounds. Materials and methods: A circular 4 cm2 excisional wound was created on the dorsum of the experimentally (Alloxan)-induced diabetic rats. In the study group (N = 24) the wound was treated with He-Ne laser (632.8 nm wavelength) at a dose of 4.8 J/cm2 for 5 days a week until the wound healed completely. The control group (N = 24) was sham-irradiated. The results were statistically analyzed by an independent t test for biochemical analysis and the nonparametric Mann-Whitney U test for histopathological parameters. Results: The analysis of the biochemical parameters and histopathological parameters of the wounds showed that the laser-treated group healed faster and better as compared to the control group (p < 0.0001). The laser-treated group healed on average by the 18th day whereas, the control group healed on average by the 59th day. Conclusion: Laser photostimulation promotes the tissue repair process of diabetic wounds.

AB - Objective: The aim of this study was to determine the effect of low-energy He-Ne laser treatment on wound healing dynamics (histological and biochemical) in diabetic rats. Background data: Low-energy laser photostimulation at certain wavelengths can enhance tissue repair by releasing growth factors from fibroblasts and can facilitate the healing process of diabetic wounds. Materials and methods: A circular 4 cm2 excisional wound was created on the dorsum of the experimentally (Alloxan)-induced diabetic rats. In the study group (N = 24) the wound was treated with He-Ne laser (632.8 nm wavelength) at a dose of 4.8 J/cm2 for 5 days a week until the wound healed completely. The control group (N = 24) was sham-irradiated. The results were statistically analyzed by an independent t test for biochemical analysis and the nonparametric Mann-Whitney U test for histopathological parameters. Results: The analysis of the biochemical parameters and histopathological parameters of the wounds showed that the laser-treated group healed faster and better as compared to the control group (p < 0.0001). The laser-treated group healed on average by the 18th day whereas, the control group healed on average by the 59th day. Conclusion: Laser photostimulation promotes the tissue repair process of diabetic wounds.

UR - http://www.scopus.com/inward/record.url?scp=19344373914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19344373914&partnerID=8YFLogxK

U2 - 10.1089/pho.2005.23.187

DO - 10.1089/pho.2005.23.187

M3 - Article

C2 - 15910184

AN - SCOPUS:19344373914

VL - 23

SP - 187

EP - 190

JO - Photomedicine and Laser Surgery

JF - Photomedicine and Laser Surgery

SN - 1549-5418

IS - 2

ER -