Effect of low level helium-neon (He-Ne) laser therapy in the prevention & treatment of radiation induced mucositis in head & neck cancer patients

G. Arun Maiya, M. S. Sagar, Donald Fernandes

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background & objectives: Oral mucositis is a common debilitating complication of radiotherapy ocurring in about 60 per cent of cancer patients. Considerable buccal toxicity of radiotherapy or chemotherapy in cancer patients to become discourage and can affect their quality of life. In addition, such toxicity can after the treatment plan. At present, there is no clinically appropriate prophylaxis efficacious antidote for mucositis. The low level laser (LEL) appears to be a simple, non-traumatic technique for the prevention and treatment of radiation induced mucositis. Therefore the present study was carried out to flnd out the the effect of low-level helium-neon (He-Ne) laser in the prevention and treatment of radiation induced mucositis in head and neck cancer patients. Methods: The patients with carcinoma of oral cavity with stages II-IV a being uniformly treated with curative total tumour dose of 66 Gy in 33 fractions over 6 wk were selected for the study. The patients were divided based on computer generated randamosization into laser (study group) and control groups with 25 patients in each group. Both study and control groups were comparable in terms of site of the lesion, stage of the cancer and histology. The study group patients were treated with He-Ne laser (wavelength 632.8 nm and output of 10mW) and control group patients were given oral analgesics, local application of anaesthetics, 0.9 per cent saline and providine wash during the course of radiotherapy. Results: All patients tolerated the laser treatment without any adverse effect or reactions. The result showed a significant difference in pain and mucositis (P<0.001) between the two groups. At the end of radiotherapy (after 6 wk) mean pain sure and mucositis grade were significantly lower (P<0.001) in the study group compared to control. Interpretation & conclusion: The low-level He-Ne laser therapy during the radiotherapy treatment was found to be effective in preventing and treating the mucositis head and neck cancer patients. Further studies need to be done on a larger sample to find the mechanism.

Original languageEnglish
Pages (from-to)399-402
Number of pages4
JournalIndian Journal of Medical Research
Volume124
Issue numberOCT.
Publication statusPublished - 01-10-2006

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Helium neon lasers
Neon
Mucositis
Gas Lasers
Radiotherapy
Laser Therapy
Head and Neck Neoplasms
Head
Radiation
Toxicity
Lasers
Povidone-Iodine
Therapeutics
Antidotes
Histology
Chemotherapy
Local Anesthetics
Control Groups
Analgesics
Tumors

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Effect of low level helium-neon (He-Ne) laser therapy in the prevention & treatment of radiation induced mucositis in head & neck cancer patients",
abstract = "Background & objectives: Oral mucositis is a common debilitating complication of radiotherapy ocurring in about 60 per cent of cancer patients. Considerable buccal toxicity of radiotherapy or chemotherapy in cancer patients to become discourage and can affect their quality of life. In addition, such toxicity can after the treatment plan. At present, there is no clinically appropriate prophylaxis efficacious antidote for mucositis. The low level laser (LEL) appears to be a simple, non-traumatic technique for the prevention and treatment of radiation induced mucositis. Therefore the present study was carried out to flnd out the the effect of low-level helium-neon (He-Ne) laser in the prevention and treatment of radiation induced mucositis in head and neck cancer patients. Methods: The patients with carcinoma of oral cavity with stages II-IV a being uniformly treated with curative total tumour dose of 66 Gy in 33 fractions over 6 wk were selected for the study. The patients were divided based on computer generated randamosization into laser (study group) and control groups with 25 patients in each group. Both study and control groups were comparable in terms of site of the lesion, stage of the cancer and histology. The study group patients were treated with He-Ne laser (wavelength 632.8 nm and output of 10mW) and control group patients were given oral analgesics, local application of anaesthetics, 0.9 per cent saline and providine wash during the course of radiotherapy. Results: All patients tolerated the laser treatment without any adverse effect or reactions. The result showed a significant difference in pain and mucositis (P<0.001) between the two groups. At the end of radiotherapy (after 6 wk) mean pain sure and mucositis grade were significantly lower (P<0.001) in the study group compared to control. Interpretation & conclusion: The low-level He-Ne laser therapy during the radiotherapy treatment was found to be effective in preventing and treating the mucositis head and neck cancer patients. Further studies need to be done on a larger sample to find the mechanism.",
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Effect of low level helium-neon (He-Ne) laser therapy in the prevention & treatment of radiation induced mucositis in head & neck cancer patients. / Maiya, G. Arun; Sagar, M. S.; Fernandes, Donald.

In: Indian Journal of Medical Research, Vol. 124, No. OCT., 01.10.2006, p. 399-402.

Research output: Contribution to journalArticle

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