Effect of lupeol isolated from Crataeva nurvala Buch.- Ham. stem bark extract against free radical induced nephrotoxicity in rats

A. Shirwaikar, M. Manjunath Setty, P. Bommu, B. Krishnanand

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Lupeol, isolated from Crataeva nurvala stem bark in doses 40 and 80 mg/kg body weight, po, for 10 days, decreased the concentration of blood urea nitrogen, creatinine and lipid peroxidation and increased glutathione and catalase activities in cisplatin (5 mg/kg body weight, ip) induced nephrotoxicity in rats. The increased glutathione and catalase activities are indicative of antioxidant properties of lupeol.
Original languageEnglish
Pages (from-to)686-690
Number of pages5
JournalIndian Journal of Experimental Biology
Volume42
Issue number7
Publication statusPublished - 2004

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Capparaceae
Catalase
Free Radicals
Glutathione
Body Weight
Blood Urea Nitrogen
Cisplatin
Lipid Peroxidation
Creatinine
Antioxidants
lupeol

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@article{7fd0d26c69604eeba4c8d45336051c05,
title = "Effect of lupeol isolated from Crataeva nurvala Buch.- Ham. stem bark extract against free radical induced nephrotoxicity in rats",
abstract = "Lupeol, isolated from Crataeva nurvala stem bark in doses 40 and 80 mg/kg body weight, po, for 10 days, decreased the concentration of blood urea nitrogen, creatinine and lipid peroxidation and increased glutathione and catalase activities in cisplatin (5 mg/kg body weight, ip) induced nephrotoxicity in rats. The increased glutathione and catalase activities are indicative of antioxidant properties of lupeol.",
author = "A. Shirwaikar and {Manjunath Setty}, M. and P. Bommu and B. Krishnanand",
note = "Cited By :23 Export Date: 10 November 2017 CODEN: IJEBA Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal Coll. of Pharmaceutical Sci., Manipal 576 104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; lupeol, 545-47-1; Cisplatin, 15663-27-1; Free Radicals; lupeol, 545-47-1; Plant Extracts; Triterpenes References: Brisha Gratna, K.L., (1981) English Translation of Sushruta Samhita, p. 7. , Chowkhamba (Sanskrit Series Office, Varanasi, India); Prabhakar, Y.S., Suresh Kumar, D., The Varuna tree, Crataeva nurvala, a promising plant in the treatment of urinary stones-A review (1990) Fitoterapia, 61, p. 99; Baskar, R., Meenalakshmi, M., Varalakshmi, P., Effect of lupeol isolated from Crataeva nurvala stem bark against free radical-induced toxicity in experimental urolithiasis (1996) Fitoterapia, 67, p. 121; Goldstein, R.S., Mayor, G.H., The nephrotoxicity of cisplatin (1983) Life Sci, 32, p. 685; McGinness, J.E., Proctor, P.H., Demopaulos, H.B., Hockanson, J.A., Kirkpatrick, D.S., Amelioration of cisplatin nephrotoxicity by orgotein (superoxide dismutase) (1978) Physiol Chem Phys, 10, p. 267; Sugihara, K., Nakano, S., Koda, M., Tanaka, K., Fukuishi, N., Gemba, M., Stimulatory effect of cisplatin on lipid peroxidation in renal tissues (1987) Jpn J Pharmacol, 43, p. 247; Sassa, H., Takaishi, Y., Terada, H., The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria (1990) Biochem Biophys Res Commun, 172, p. 890; Balanehru, S., Nagarajan, B., Protective effect of oleanolic acid and ursolic acid against lipid peroxidation (1991) Biochem Int, 24, p. 981; Badami, S., Manoharareddy, S.A., Mathew, N., Suresh, B., Distribution and biological activities of lupeol (2003) Indian Drugs, 40, p. 255; Henry, R.J., (1963) Clin Chem Priciple and Techniques, p. 268. , Newyork, Harper & Row; Mayne, P.D., Diagnosis of renal function (1994) Clinical Chemistry in Diagnosis and Treatment, p. 1. , ELBS, London; Tietz, N.W., (1986) Fundamentals of Clinical Chemistry, p. 1278. , WB Saundars and company Philadelphia; Fraga, C.G., Leibovitz, B.E., Tappel, A.I., Lipid peroxidation measured as TBARS in tissue slices: Characterisation and comparison with homogenates and microsomes (1988) Free Radic Biol Med, 4, p. 155; Ellman, G.L., Tissue sulphydryl groups (1959) Arch Biochem Biophys, 82, p. 70; Sinha, K.A., Colorimetric assay of catalase (1972) Annal Biochem, 47, p. 389; Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with folin-phenol reagent (1951) J Biol Chem, 193, p. 265; Fantone, J.C., Ward, P.A., Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions (1992) Am J Pathol, 107, p. 397; Weiss, S.J., LoBuglio, A.F., Phagocyte-generated oxygen metabolites and cell injury (1982) Lab Invest, 47, p. 5; Varani, J., Fligiel, S.E., Till, G.O., Kunkel, R.G., Ryan, U.S., Ward, P.A., Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical (1985) Lab Invest, 53, p. 656; Fox, R.B., Prevention of granulocyte-mediated oxidative injury in rats by a hydroxyl radical scavenger, dimethylthiocarbide (1984) J Clin Invest, 74, p. 1456; Shah, S.V., Effect of enzymatically generated reactive oxygen metabolites on the cyclic nucleotide content in isolated glomeruli (1984) J Clin Invest, 74, p. 393; Shah, S.V., Barcos, W.H., Basci, A., Degradation of human glomerular basement membrane by stimulated neutrophils: Activation of a metallaproteinase by reactive oxygen metabolite (1987) J Clin Invest, 79, p. 25; Zhang, J.G., Lindup, W.E., Cisplatin nephrotoxicity decreases in mitochondrial protein sulfhydryl concentration and calcium uptake by mitochondria from rat renal cortical slices (1994) Biochem Pharmacol, 47, p. 1127; Bramley, P.M., Pridham, J.B., The relative antioxidant activities of plant derived polyphenolic flavanoids (1995) Free Radical Res, 4, p. 375; Sdzuka, Y., Shoji, T., Takino, Y., Effect of cisplatin on the activation of enzymes which protect against lipid peroxidation (1992) Biochem Pharmacol, 43, p. 1872; Kim, Y.K., Jung, J.S., Lee, S.H., Kim, Y.W., Effects of antioxidants and calcium in cisplatin-induced cell injury in rabbit renal cortical slices (1997) Toxicol Appl Pharmacol, 146, p. 261",
year = "2004",
language = "English",
volume = "42",
pages = "686--690",
journal = "Journal of scientific & industrial research. C. Biological sciences",
issn = "0019-5189",
publisher = "National Institute of Science Communication",
number = "7",

}

Effect of lupeol isolated from Crataeva nurvala Buch.- Ham. stem bark extract against free radical induced nephrotoxicity in rats. / Shirwaikar, A.; Manjunath Setty, M.; Bommu, P.; Krishnanand, B.

In: Indian Journal of Experimental Biology, Vol. 42, No. 7, 2004, p. 686-690.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of lupeol isolated from Crataeva nurvala Buch.- Ham. stem bark extract against free radical induced nephrotoxicity in rats

AU - Shirwaikar, A.

AU - Manjunath Setty, M.

AU - Bommu, P.

AU - Krishnanand, B.

N1 - Cited By :23 Export Date: 10 November 2017 CODEN: IJEBA Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal Coll. of Pharmaceutical Sci., Manipal 576 104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; lupeol, 545-47-1; Cisplatin, 15663-27-1; Free Radicals; lupeol, 545-47-1; Plant Extracts; Triterpenes References: Brisha Gratna, K.L., (1981) English Translation of Sushruta Samhita, p. 7. , Chowkhamba (Sanskrit Series Office, Varanasi, India); Prabhakar, Y.S., Suresh Kumar, D., The Varuna tree, Crataeva nurvala, a promising plant in the treatment of urinary stones-A review (1990) Fitoterapia, 61, p. 99; Baskar, R., Meenalakshmi, M., Varalakshmi, P., Effect of lupeol isolated from Crataeva nurvala stem bark against free radical-induced toxicity in experimental urolithiasis (1996) Fitoterapia, 67, p. 121; Goldstein, R.S., Mayor, G.H., The nephrotoxicity of cisplatin (1983) Life Sci, 32, p. 685; McGinness, J.E., Proctor, P.H., Demopaulos, H.B., Hockanson, J.A., Kirkpatrick, D.S., Amelioration of cisplatin nephrotoxicity by orgotein (superoxide dismutase) (1978) Physiol Chem Phys, 10, p. 267; Sugihara, K., Nakano, S., Koda, M., Tanaka, K., Fukuishi, N., Gemba, M., Stimulatory effect of cisplatin on lipid peroxidation in renal tissues (1987) Jpn J Pharmacol, 43, p. 247; Sassa, H., Takaishi, Y., Terada, H., The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria (1990) Biochem Biophys Res Commun, 172, p. 890; Balanehru, S., Nagarajan, B., Protective effect of oleanolic acid and ursolic acid against lipid peroxidation (1991) Biochem Int, 24, p. 981; Badami, S., Manoharareddy, S.A., Mathew, N., Suresh, B., Distribution and biological activities of lupeol (2003) Indian Drugs, 40, p. 255; Henry, R.J., (1963) Clin Chem Priciple and Techniques, p. 268. , Newyork, Harper & Row; Mayne, P.D., Diagnosis of renal function (1994) Clinical Chemistry in Diagnosis and Treatment, p. 1. , ELBS, London; Tietz, N.W., (1986) Fundamentals of Clinical Chemistry, p. 1278. , WB Saundars and company Philadelphia; Fraga, C.G., Leibovitz, B.E., Tappel, A.I., Lipid peroxidation measured as TBARS in tissue slices: Characterisation and comparison with homogenates and microsomes (1988) Free Radic Biol Med, 4, p. 155; Ellman, G.L., Tissue sulphydryl groups (1959) Arch Biochem Biophys, 82, p. 70; Sinha, K.A., Colorimetric assay of catalase (1972) Annal Biochem, 47, p. 389; Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with folin-phenol reagent (1951) J Biol Chem, 193, p. 265; Fantone, J.C., Ward, P.A., Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions (1992) Am J Pathol, 107, p. 397; Weiss, S.J., LoBuglio, A.F., Phagocyte-generated oxygen metabolites and cell injury (1982) Lab Invest, 47, p. 5; Varani, J., Fligiel, S.E., Till, G.O., Kunkel, R.G., Ryan, U.S., Ward, P.A., Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical (1985) Lab Invest, 53, p. 656; Fox, R.B., Prevention of granulocyte-mediated oxidative injury in rats by a hydroxyl radical scavenger, dimethylthiocarbide (1984) J Clin Invest, 74, p. 1456; Shah, S.V., Effect of enzymatically generated reactive oxygen metabolites on the cyclic nucleotide content in isolated glomeruli (1984) J Clin Invest, 74, p. 393; Shah, S.V., Barcos, W.H., Basci, A., Degradation of human glomerular basement membrane by stimulated neutrophils: Activation of a metallaproteinase by reactive oxygen metabolite (1987) J Clin Invest, 79, p. 25; Zhang, J.G., Lindup, W.E., Cisplatin nephrotoxicity decreases in mitochondrial protein sulfhydryl concentration and calcium uptake by mitochondria from rat renal cortical slices (1994) Biochem Pharmacol, 47, p. 1127; Bramley, P.M., Pridham, J.B., The relative antioxidant activities of plant derived polyphenolic flavanoids (1995) Free Radical Res, 4, p. 375; Sdzuka, Y., Shoji, T., Takino, Y., Effect of cisplatin on the activation of enzymes which protect against lipid peroxidation (1992) Biochem Pharmacol, 43, p. 1872; Kim, Y.K., Jung, J.S., Lee, S.H., Kim, Y.W., Effects of antioxidants and calcium in cisplatin-induced cell injury in rabbit renal cortical slices (1997) Toxicol Appl Pharmacol, 146, p. 261

PY - 2004

Y1 - 2004

N2 - Lupeol, isolated from Crataeva nurvala stem bark in doses 40 and 80 mg/kg body weight, po, for 10 days, decreased the concentration of blood urea nitrogen, creatinine and lipid peroxidation and increased glutathione and catalase activities in cisplatin (5 mg/kg body weight, ip) induced nephrotoxicity in rats. The increased glutathione and catalase activities are indicative of antioxidant properties of lupeol.

AB - Lupeol, isolated from Crataeva nurvala stem bark in doses 40 and 80 mg/kg body weight, po, for 10 days, decreased the concentration of blood urea nitrogen, creatinine and lipid peroxidation and increased glutathione and catalase activities in cisplatin (5 mg/kg body weight, ip) induced nephrotoxicity in rats. The increased glutathione and catalase activities are indicative of antioxidant properties of lupeol.

M3 - Article

VL - 42

SP - 686

EP - 690

JO - Journal of scientific & industrial research. C. Biological sciences

JF - Journal of scientific & industrial research. C. Biological sciences

SN - 0019-5189

IS - 7

ER -