Effect of macrophage activation on niosome encapsulated bleomycin in tumor bearing mice

R. A. Raja Naresh, N. Udupa, P. Uma Devi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Anticancer therapy can be made more effective by targeting the delivery of anticancer drugs to the tumor site more quantitatively. In this direction attempts have been made to activate and exploit macrophages in delivering niosomal and thermosensitive niosomal bleomycin more quantitatively to tumor site using niosome encapsulated immunomodulators muramyl dipeptide and tuftsin. Niosomal bleomycin and thermosensitive niosomal bleomycin were prepared by lipid layer hydration method. The antitumor efficacy was assessed using two tumor models viz. Sarcoma-180 and Ehrlich ascites using Balb/C mice. Tumor distribution profiles of bleomycin before and after macrophage activation were studied in tumor bearing mice. The mean survival time of Ehrlich ascites infected mice increased significantly after macrophage activation. Accumulation of higher bleomycin levels after macrophage activation exerted increased antitumor effect. The present study suggested that a more quantitative delivery of bleomycin encapsulated in niosomes, to the tumor site is possible after macrophage activation.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalIndian Journal of Pharmacology
Volume28
Issue number3
Publication statusPublished - 09-1996

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Macrophage Activation
Liposomes
Bleomycin
Neoplasms
Ascites
Tuftsin
Acetylmuramyl-Alanyl-Isoglutamine
Sarcoma 180
Immunologic Factors
indium-bleomycin
Macrophages
Lipids
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

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Effect of macrophage activation on niosome encapsulated bleomycin in tumor bearing mice. / Raja Naresh, R. A.; Udupa, N.; Uma Devi, P.

In: Indian Journal of Pharmacology, Vol. 28, No. 3, 09.1996, p. 175-180.

Research output: Contribution to journalArticle

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