Effect of morinda citrifolia (Noni) fruit juice on high fat diet induced dyslipidemia in rats

Ahsan Shoeb, M. C. Alwar, Preethi J. Shenoy, P. Gokul

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: The medicinal value of Morinda citrifolia L. (commonly known as Noni) has been explored in ancient folk remedies with a wide range of therapeutic utility, including antibacterial, antiviral, antifungal, antitumour, analgesic, hypotensive, anti-inflammatory and immune enhancing effects. Aim: The present study was designed to evaluate the effects of Noni fruit juice on serum lipid profile in high fat diet induced murine model of dyslipidemia. Materials and Methods: Hyperlipidemia was induced by feeding a cholesterol rich high fat diet for 45 days in wistar albino rats of either sex (n=8). Noni fruit juice administered at 50mg/kg/day and 100mg/kg/day, per oral, was compared with the standard drug Atorvastatin (10mg/kg/day, oral) fed for the latter 30 days. The blood samples were then sent for complete blood lipid profile, after 30 days of treatment. The data presented as mean ± SEM was analyzed using one-way ANOVA followed by Tukey’s post-hoc test. The p <0.05 was considered as statistically significant. Results: The Noni fruit juice treated group showed a significant decrease in the total cholesterol, triglycerides and very low density lipoprotein - Cholesterol at both the doses when compared to the disease control (P<0.05). However, the decrease in the TC (102.75±9.79 mg/dL) and LDL-C (47.87±7.47 mg/dL) levels observed with the noni fruit juice at the 50mg/kg dose employed, failed to show a statistical significance when compared to atorvastatin. Conclusion: The present study provides evidence for the hypolipidemic activity of Noni fruit juice in high fat diet induced hyperlipidemia in rats.

Original languageEnglish
Pages (from-to)FF06-FF10
JournalJournal of Clinical and Diagnostic Research
Volume10
Issue number4
DOIs
Publication statusPublished - 01-04-2016

Fingerprint

Morinda
Fruit juices
High Fat Diet
Nutrition
Dyslipidemias
Rats
Fats
Blood
Cholesterol
Hyperlipidemias
Disease control
Lipids
VLDL Cholesterol
Analysis of variance (ANOVA)
Antiviral Agents
Analgesics
Anti-Inflammatory Agents
Traditional Medicine
Non-Steroidal Anti-Inflammatory Agents
Fruit and Vegetable Juices

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

@article{5c27ce9f7eba4cbf842e50c82b833ffd,
title = "Effect of morinda citrifolia (Noni) fruit juice on high fat diet induced dyslipidemia in rats",
abstract = "Introduction: The medicinal value of Morinda citrifolia L. (commonly known as Noni) has been explored in ancient folk remedies with a wide range of therapeutic utility, including antibacterial, antiviral, antifungal, antitumour, analgesic, hypotensive, anti-inflammatory and immune enhancing effects. Aim: The present study was designed to evaluate the effects of Noni fruit juice on serum lipid profile in high fat diet induced murine model of dyslipidemia. Materials and Methods: Hyperlipidemia was induced by feeding a cholesterol rich high fat diet for 45 days in wistar albino rats of either sex (n=8). Noni fruit juice administered at 50mg/kg/day and 100mg/kg/day, per oral, was compared with the standard drug Atorvastatin (10mg/kg/day, oral) fed for the latter 30 days. The blood samples were then sent for complete blood lipid profile, after 30 days of treatment. The data presented as mean ± SEM was analyzed using one-way ANOVA followed by Tukey’s post-hoc test. The p <0.05 was considered as statistically significant. Results: The Noni fruit juice treated group showed a significant decrease in the total cholesterol, triglycerides and very low density lipoprotein - Cholesterol at both the doses when compared to the disease control (P<0.05). However, the decrease in the TC (102.75±9.79 mg/dL) and LDL-C (47.87±7.47 mg/dL) levels observed with the noni fruit juice at the 50mg/kg dose employed, failed to show a statistical significance when compared to atorvastatin. Conclusion: The present study provides evidence for the hypolipidemic activity of Noni fruit juice in high fat diet induced hyperlipidemia in rats.",
author = "Ahsan Shoeb and Alwar, {M. C.} and Shenoy, {Preethi J.} and P. Gokul",
year = "2016",
month = "4",
day = "1",
doi = "10.7860/JCDR/2016/17900.7650",
language = "English",
volume = "10",
pages = "FF06--FF10",
journal = "Journal of Clinical and Diagnostic Research",
issn = "2249-782X",
publisher = "Journal of Clinical and Diagnostic Research",
number = "4",

}

Effect of morinda citrifolia (Noni) fruit juice on high fat diet induced dyslipidemia in rats. / Shoeb, Ahsan; Alwar, M. C.; Shenoy, Preethi J.; Gokul, P.

In: Journal of Clinical and Diagnostic Research, Vol. 10, No. 4, 01.04.2016, p. FF06-FF10.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of morinda citrifolia (Noni) fruit juice on high fat diet induced dyslipidemia in rats

AU - Shoeb, Ahsan

AU - Alwar, M. C.

AU - Shenoy, Preethi J.

AU - Gokul, P.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Introduction: The medicinal value of Morinda citrifolia L. (commonly known as Noni) has been explored in ancient folk remedies with a wide range of therapeutic utility, including antibacterial, antiviral, antifungal, antitumour, analgesic, hypotensive, anti-inflammatory and immune enhancing effects. Aim: The present study was designed to evaluate the effects of Noni fruit juice on serum lipid profile in high fat diet induced murine model of dyslipidemia. Materials and Methods: Hyperlipidemia was induced by feeding a cholesterol rich high fat diet for 45 days in wistar albino rats of either sex (n=8). Noni fruit juice administered at 50mg/kg/day and 100mg/kg/day, per oral, was compared with the standard drug Atorvastatin (10mg/kg/day, oral) fed for the latter 30 days. The blood samples were then sent for complete blood lipid profile, after 30 days of treatment. The data presented as mean ± SEM was analyzed using one-way ANOVA followed by Tukey’s post-hoc test. The p <0.05 was considered as statistically significant. Results: The Noni fruit juice treated group showed a significant decrease in the total cholesterol, triglycerides and very low density lipoprotein - Cholesterol at both the doses when compared to the disease control (P<0.05). However, the decrease in the TC (102.75±9.79 mg/dL) and LDL-C (47.87±7.47 mg/dL) levels observed with the noni fruit juice at the 50mg/kg dose employed, failed to show a statistical significance when compared to atorvastatin. Conclusion: The present study provides evidence for the hypolipidemic activity of Noni fruit juice in high fat diet induced hyperlipidemia in rats.

AB - Introduction: The medicinal value of Morinda citrifolia L. (commonly known as Noni) has been explored in ancient folk remedies with a wide range of therapeutic utility, including antibacterial, antiviral, antifungal, antitumour, analgesic, hypotensive, anti-inflammatory and immune enhancing effects. Aim: The present study was designed to evaluate the effects of Noni fruit juice on serum lipid profile in high fat diet induced murine model of dyslipidemia. Materials and Methods: Hyperlipidemia was induced by feeding a cholesterol rich high fat diet for 45 days in wistar albino rats of either sex (n=8). Noni fruit juice administered at 50mg/kg/day and 100mg/kg/day, per oral, was compared with the standard drug Atorvastatin (10mg/kg/day, oral) fed for the latter 30 days. The blood samples were then sent for complete blood lipid profile, after 30 days of treatment. The data presented as mean ± SEM was analyzed using one-way ANOVA followed by Tukey’s post-hoc test. The p <0.05 was considered as statistically significant. Results: The Noni fruit juice treated group showed a significant decrease in the total cholesterol, triglycerides and very low density lipoprotein - Cholesterol at both the doses when compared to the disease control (P<0.05). However, the decrease in the TC (102.75±9.79 mg/dL) and LDL-C (47.87±7.47 mg/dL) levels observed with the noni fruit juice at the 50mg/kg dose employed, failed to show a statistical significance when compared to atorvastatin. Conclusion: The present study provides evidence for the hypolipidemic activity of Noni fruit juice in high fat diet induced hyperlipidemia in rats.

UR - http://www.scopus.com/inward/record.url?scp=84963787382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963787382&partnerID=8YFLogxK

U2 - 10.7860/JCDR/2016/17900.7650

DO - 10.7860/JCDR/2016/17900.7650

M3 - Article

AN - SCOPUS:84963787382

VL - 10

SP - FF06-FF10

JO - Journal of Clinical and Diagnostic Research

JF - Journal of Clinical and Diagnostic Research

SN - 2249-782X

IS - 4

ER -