Effect of niosome encapsulation of methotrexate, macrophage activation on tissue distribution of methotrexate and tumor size

K. S. Chandraprakash, N. Udupa, P. Uma Devi, G. K. Pillai

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12 Citations (Scopus)


Methotrexate was encapsulated in "niosomes" of sorbitan monostearate (Span 60) by the reverse phase evaporation technique. After i.v. infusion into mice methotrexate concentration was higher in all tissues except kidney with niosomal methotrexate than with methotrexate solution. Niosome encapsulation and macrophage activation enhanced the delivery of methotrexate to the tumor and increased its antitumor activity.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalDrug Delivery
Issue number2
Publication statusPublished - 1993


All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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