Effect of niosome encapsulation of methotrexate, macrophage activation on tissue distribution of methotrexate and tumor size

K. S. Chandraprakash, N. Udupa, P. Uma Devi, G. K. Pillai

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Abstract

Methotrexate was encapsulated in "niosomes" of sorbitan monostearate (Span 60) by the reverse phase evaporation technique. After i.v. infusion into mice methotrexate concentration was higher in all tissues except kidney with niosomal methotrexate than with methotrexate solution. Niosome encapsulation and macrophage activation enhanced the delivery of methotrexate to the tumor and increased its antitumor activity.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalDrug Delivery
Volume1
Issue number2
DOIs
Publication statusPublished - 1993

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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