Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice

Shri Vinod Nair, Albina Arjuman, P. Dorababu, H. N. Gopalakrishna, U. Chakradhar Rao, Lalit Mohan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background & objectives: Use of typical antipsychotics like haloperidol in treatment of schizophrenia is associated with a high incidence of extrapyramidal side effects. In rodents, administration of haloperidol leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture. In the present study we evaluated the anticataleptic efficacy of NR-ANX-C, a polyherbal formulation containing bioactives of Withania somnifera, Ocimum sanctum, Camellia sinensis, triphala and shilajit in haloperidol induced catalepsy in mice. Methods: Five groups (n = 6) of male albino mice were used in the study. Catalepsy was induced by ip administration of haloperidol (1mg/kg). The degree ot catalepsy (cataleptic score) was measured as the time the animal maintained an imposed posture. We compared the anticataleptic efficacy of NR-ANX-C (10, 25 and 50 mg/kg) with scopolamine (1 mg/kg). The superoxide dismutase (SOD) level in brain tissue was also estimated to correlate the levels of oxidative stress and degree of catalepsy in the animal. Results: Significant (P<0.01) reduction in the cataleptic scores was observed in all NR-ANX-C treated groups and maximum reduction was observed in the NR-ANX-C (25 mg/kg) treated group. Significant (P<0.05) reduction in SOD activity was observed in NR-ANX-C (25 and 50 mg/kg) treated groups and maximum reduction was observed in NR-ANX-C (25mg/kg) treated group. Interpretation & conclusions: In our study, maximum reduction in cataleptic score was observed in NR-ANX-C (25 mg/kg) treated group. The maximum reduction in SOD activity was also observed in the same group. These findings suggest a possible involvement of the antioxidant potential of NR-ANX-C in alleviating haloperidol induced catalepsy.

Original languageEnglish
Pages (from-to)480-484
Number of pages5
JournalIndian Journal of Medical Research
Volume126
Issue number5
Publication statusPublished - 01-11-2007
Externally publishedYes

Fingerprint

Catalepsy
Haloperidol
Superoxide Dismutase
Animals
Posture
Withania
Camellia sinensis
Oxidative stress
Scopolamine Hydrobromide
NR-ANX-C
Antipsychotic Agents
Rodentia
Brain
Schizophrenia
Oxidative Stress
Antioxidants
Tissue
Incidence

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nair, S. V., Arjuman, A., Dorababu, P., Gopalakrishna, H. N., Rao, U. C., & Mohan, L. (2007). Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice. Indian Journal of Medical Research, 126(5), 480-484.
Nair, Shri Vinod ; Arjuman, Albina ; Dorababu, P. ; Gopalakrishna, H. N. ; Rao, U. Chakradhar ; Mohan, Lalit. / Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice. In: Indian Journal of Medical Research. 2007 ; Vol. 126, No. 5. pp. 480-484.
@article{6a88bf252f7448918634301a400307e2,
title = "Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice",
abstract = "Background & objectives: Use of typical antipsychotics like haloperidol in treatment of schizophrenia is associated with a high incidence of extrapyramidal side effects. In rodents, administration of haloperidol leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture. In the present study we evaluated the anticataleptic efficacy of NR-ANX-C, a polyherbal formulation containing bioactives of Withania somnifera, Ocimum sanctum, Camellia sinensis, triphala and shilajit in haloperidol induced catalepsy in mice. Methods: Five groups (n = 6) of male albino mice were used in the study. Catalepsy was induced by ip administration of haloperidol (1mg/kg). The degree ot catalepsy (cataleptic score) was measured as the time the animal maintained an imposed posture. We compared the anticataleptic efficacy of NR-ANX-C (10, 25 and 50 mg/kg) with scopolamine (1 mg/kg). The superoxide dismutase (SOD) level in brain tissue was also estimated to correlate the levels of oxidative stress and degree of catalepsy in the animal. Results: Significant (P<0.01) reduction in the cataleptic scores was observed in all NR-ANX-C treated groups and maximum reduction was observed in the NR-ANX-C (25 mg/kg) treated group. Significant (P<0.05) reduction in SOD activity was observed in NR-ANX-C (25 and 50 mg/kg) treated groups and maximum reduction was observed in NR-ANX-C (25mg/kg) treated group. Interpretation & conclusions: In our study, maximum reduction in cataleptic score was observed in NR-ANX-C (25 mg/kg) treated group. The maximum reduction in SOD activity was also observed in the same group. These findings suggest a possible involvement of the antioxidant potential of NR-ANX-C in alleviating haloperidol induced catalepsy.",
author = "Nair, {Shri Vinod} and Albina Arjuman and P. Dorababu and Gopalakrishna, {H. N.} and Rao, {U. Chakradhar} and Lalit Mohan",
year = "2007",
month = "11",
day = "1",
language = "English",
volume = "126",
pages = "480--484",
journal = "Indian Journal of Medical Research",
issn = "0971-5916",
publisher = "Indian Council of Medical Research",
number = "5",

}

Nair, SV, Arjuman, A, Dorababu, P, Gopalakrishna, HN, Rao, UC & Mohan, L 2007, 'Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice', Indian Journal of Medical Research, vol. 126, no. 5, pp. 480-484.

Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice. / Nair, Shri Vinod; Arjuman, Albina; Dorababu, P.; Gopalakrishna, H. N.; Rao, U. Chakradhar; Mohan, Lalit.

In: Indian Journal of Medical Research, Vol. 126, No. 5, 01.11.2007, p. 480-484.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice

AU - Nair, Shri Vinod

AU - Arjuman, Albina

AU - Dorababu, P.

AU - Gopalakrishna, H. N.

AU - Rao, U. Chakradhar

AU - Mohan, Lalit

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Background & objectives: Use of typical antipsychotics like haloperidol in treatment of schizophrenia is associated with a high incidence of extrapyramidal side effects. In rodents, administration of haloperidol leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture. In the present study we evaluated the anticataleptic efficacy of NR-ANX-C, a polyherbal formulation containing bioactives of Withania somnifera, Ocimum sanctum, Camellia sinensis, triphala and shilajit in haloperidol induced catalepsy in mice. Methods: Five groups (n = 6) of male albino mice were used in the study. Catalepsy was induced by ip administration of haloperidol (1mg/kg). The degree ot catalepsy (cataleptic score) was measured as the time the animal maintained an imposed posture. We compared the anticataleptic efficacy of NR-ANX-C (10, 25 and 50 mg/kg) with scopolamine (1 mg/kg). The superoxide dismutase (SOD) level in brain tissue was also estimated to correlate the levels of oxidative stress and degree of catalepsy in the animal. Results: Significant (P<0.01) reduction in the cataleptic scores was observed in all NR-ANX-C treated groups and maximum reduction was observed in the NR-ANX-C (25 mg/kg) treated group. Significant (P<0.05) reduction in SOD activity was observed in NR-ANX-C (25 and 50 mg/kg) treated groups and maximum reduction was observed in NR-ANX-C (25mg/kg) treated group. Interpretation & conclusions: In our study, maximum reduction in cataleptic score was observed in NR-ANX-C (25 mg/kg) treated group. The maximum reduction in SOD activity was also observed in the same group. These findings suggest a possible involvement of the antioxidant potential of NR-ANX-C in alleviating haloperidol induced catalepsy.

AB - Background & objectives: Use of typical antipsychotics like haloperidol in treatment of schizophrenia is associated with a high incidence of extrapyramidal side effects. In rodents, administration of haloperidol leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture. In the present study we evaluated the anticataleptic efficacy of NR-ANX-C, a polyherbal formulation containing bioactives of Withania somnifera, Ocimum sanctum, Camellia sinensis, triphala and shilajit in haloperidol induced catalepsy in mice. Methods: Five groups (n = 6) of male albino mice were used in the study. Catalepsy was induced by ip administration of haloperidol (1mg/kg). The degree ot catalepsy (cataleptic score) was measured as the time the animal maintained an imposed posture. We compared the anticataleptic efficacy of NR-ANX-C (10, 25 and 50 mg/kg) with scopolamine (1 mg/kg). The superoxide dismutase (SOD) level in brain tissue was also estimated to correlate the levels of oxidative stress and degree of catalepsy in the animal. Results: Significant (P<0.01) reduction in the cataleptic scores was observed in all NR-ANX-C treated groups and maximum reduction was observed in the NR-ANX-C (25 mg/kg) treated group. Significant (P<0.05) reduction in SOD activity was observed in NR-ANX-C (25 and 50 mg/kg) treated groups and maximum reduction was observed in NR-ANX-C (25mg/kg) treated group. Interpretation & conclusions: In our study, maximum reduction in cataleptic score was observed in NR-ANX-C (25 mg/kg) treated group. The maximum reduction in SOD activity was also observed in the same group. These findings suggest a possible involvement of the antioxidant potential of NR-ANX-C in alleviating haloperidol induced catalepsy.

UR - http://www.scopus.com/inward/record.url?scp=43049162918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43049162918&partnerID=8YFLogxK

M3 - Article

VL - 126

SP - 480

EP - 484

JO - Indian Journal of Medical Research

JF - Indian Journal of Medical Research

SN - 0971-5916

IS - 5

ER -

Nair SV, Arjuman A, Dorababu P, Gopalakrishna HN, Rao UC, Mohan L. Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice. Indian Journal of Medical Research. 2007 Nov 1;126(5):480-484.