Effect of Ocimum sanctum (Linn) extract on restraint stress induced behavioral deficits in male wistar rats

Raju Suresh Kumar, Muddanna S. Rao, Satheesha Nayak, N. N. Sareesh

Research output: Contribution to journalArticle

8 Citations (Scopus)


Ocimum sanctum plant extract was screened for its effects on restraint stress induced behavioral changes in Morris water maze and passive avoidance task. Restraint stress for 21 days caused memory impairment in rats. Animals treated with 100mg/kg body weight of Ocimum sanctum plant extract, by oral feeding during stress, showed a decreased latency to enter the target quadrant in Morris water maze test compared to the stressed animals. Ocimum sanctum treated animals also showed increase in latency to enter the dark compartment during retention test in passive avoidance tests both after 24hours and 48hours. These results reveal the memory enhancing effects of Ocimum Sanctum plant in restraint stress induced memory impaired rats.

Original languageEnglish
Pages (from-to)394-404
Number of pages11
Publication statusPublished - 01-12-2007


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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