Effect of Ocimum sanctum Linn. on normal and dexamethasone suppressed wound healing

S. L. Udupa, Somashekar Shetty, A. L. Udupa, S. N. Somayaji

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Ethanolic extract of leaves of O. sanctum was investigated for normal wound healing and dexamethasone depressed healing using incision, excision and dead space wound models in albino rats. The extract of O. sanctum significantly increased the wound breaking strength in incision wound model. The extract treated wounds were found to epithelialize faster and the rate of wound contraction was significantly increased as compared to control wounds. Significant increase in wet and dry granulation tissue weight, granulation tissue breaking strength and hydroxyproline content in dead space wound model was observed. The extract significantly decreased the antihealing activities of dexamethasone in all the wound models. The results indicated that the leaf extract promotes wound healing significantly and able to overcome the wound healing suppressing action of dexamethasone. Histological examination of granulation tissue to determine the pattern of laydown for collagen confirmed the results.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalIndian Journal of Experimental Biology
Volume44
Issue number1
Publication statusPublished - 01-01-2006

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

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