Objective: To evaluate the effect of ethanolic extract of Phyllanthus niruri. Linn (Euphorbiaceae) on experimentally induced burn wound model in rats and to evaluate whether it reverses the wound healing in steroid suppressed rats. Methods: Two models including burn wound model and dexamethasone suppressed burn wound model were used in the study. The formulations of ethanolic extract of Phyllanthus niruri were prepared in gum acacia at 8% and in ointment base at 10% and were administered orally (400 mg/kg) and externally respectively. The parameters studied were the wound contraction and the period of epithelialisation. Results: In burn wound model, oral and topical administration of Phyllanthus niruri did not show any significant effects in wound contraction and period of epithelialisation when compared to control. In dexamethasone suppressed burn wound model, wound contraction rate was increased significantly by topical (P < 0.001) and oral (P < 0.001) administrations of Phyllanthus niruri by about 47.57% and 26.16% respectively. Topical administration has shown significant (P < 0.05) enhancement of wound contraction than oral dosage form. Dexamethasone depressed epithelialisation period was reversed significantly by topical (P < 0.0001) and oral (P <0.001) administrations of Phyllanthus niruri by about 32.5% and 21.3% respectively. Conclusions: Both topical and oral administrations of ethanolic extract of Phyllanthus niruri are found to reverse dexamethasone suppressed burn wound healing.
All Science Journal Classification (ASJC) codes