Effect of Phyllanthus niruri. Linn on burn wound in rats

Tara Shanbhag, Arul Amuthan, Smita Shenoy, Sudhakar

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the effect of ethanolic extract of Phyllanthus niruri. Linn (Euphorbiaceae) on experimentally induced burn wound model in rats and to evaluate whether it reverses the wound healing in steroid suppressed rats. Methods: Two models including burn wound model and dexamethasone suppressed burn wound model were used in the study. The formulations of ethanolic extract of Phyllanthus niruri were prepared in gum acacia at 8% and in ointment base at 10% and were administered orally (400 mg/kg) and externally respectively. The parameters studied were the wound contraction and the period of epithelialisation. Results: In burn wound model, oral and topical administration of Phyllanthus niruri did not show any significant effects in wound contraction and period of epithelialisation when compared to control. In dexamethasone suppressed burn wound model, wound contraction rate was increased significantly by topical (P < 0.001) and oral (P < 0.001) administrations of Phyllanthus niruri by about 47.57% and 26.16% respectively. Topical administration has shown significant (P < 0.05) enhancement of wound contraction than oral dosage form. Dexamethasone depressed epithelialisation period was reversed significantly by topical (P < 0.0001) and oral (P <0.001) administrations of Phyllanthus niruri by about 32.5% and 21.3% respectively. Conclusions: Both topical and oral administrations of ethanolic extract of Phyllanthus niruri are found to reverse dexamethasone suppressed burn wound healing.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalAsian Pacific Journal of Tropical Medicine
Volume3
Issue number2
DOIs
Publication statusPublished - 01-02-2010

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Phyllanthus
Wounds and Injuries
Topical Administration
Dexamethasone
Oral Administration
Wound Healing
Ointment Bases
Gum Arabic
Euphorbiaceae
Dosage Forms
Steroids

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{147a699dccc54f228338d6c8f5285ce7,
title = "Effect of Phyllanthus niruri. Linn on burn wound in rats",
abstract = "Objective: To evaluate the effect of ethanolic extract of Phyllanthus niruri. Linn (Euphorbiaceae) on experimentally induced burn wound model in rats and to evaluate whether it reverses the wound healing in steroid suppressed rats. Methods: Two models including burn wound model and dexamethasone suppressed burn wound model were used in the study. The formulations of ethanolic extract of Phyllanthus niruri were prepared in gum acacia at 8{\%} and in ointment base at 10{\%} and were administered orally (400 mg/kg) and externally respectively. The parameters studied were the wound contraction and the period of epithelialisation. Results: In burn wound model, oral and topical administration of Phyllanthus niruri did not show any significant effects in wound contraction and period of epithelialisation when compared to control. In dexamethasone suppressed burn wound model, wound contraction rate was increased significantly by topical (P < 0.001) and oral (P < 0.001) administrations of Phyllanthus niruri by about 47.57{\%} and 26.16{\%} respectively. Topical administration has shown significant (P < 0.05) enhancement of wound contraction than oral dosage form. Dexamethasone depressed epithelialisation period was reversed significantly by topical (P < 0.0001) and oral (P <0.001) administrations of Phyllanthus niruri by about 32.5{\%} and 21.3{\%} respectively. Conclusions: Both topical and oral administrations of ethanolic extract of Phyllanthus niruri are found to reverse dexamethasone suppressed burn wound healing.",
author = "Tara Shanbhag and Arul Amuthan and Smita Shenoy and Sudhakar",
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Effect of Phyllanthus niruri. Linn on burn wound in rats. / Shanbhag, Tara; Amuthan, Arul; Shenoy, Smita; Sudhakar.

In: Asian Pacific Journal of Tropical Medicine, Vol. 3, No. 2, 01.02.2010, p. 105-108.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of Phyllanthus niruri. Linn on burn wound in rats

AU - Shanbhag, Tara

AU - Amuthan, Arul

AU - Shenoy, Smita

AU - Sudhakar,

PY - 2010/2/1

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N2 - Objective: To evaluate the effect of ethanolic extract of Phyllanthus niruri. Linn (Euphorbiaceae) on experimentally induced burn wound model in rats and to evaluate whether it reverses the wound healing in steroid suppressed rats. Methods: Two models including burn wound model and dexamethasone suppressed burn wound model were used in the study. The formulations of ethanolic extract of Phyllanthus niruri were prepared in gum acacia at 8% and in ointment base at 10% and were administered orally (400 mg/kg) and externally respectively. The parameters studied were the wound contraction and the period of epithelialisation. Results: In burn wound model, oral and topical administration of Phyllanthus niruri did not show any significant effects in wound contraction and period of epithelialisation when compared to control. In dexamethasone suppressed burn wound model, wound contraction rate was increased significantly by topical (P < 0.001) and oral (P < 0.001) administrations of Phyllanthus niruri by about 47.57% and 26.16% respectively. Topical administration has shown significant (P < 0.05) enhancement of wound contraction than oral dosage form. Dexamethasone depressed epithelialisation period was reversed significantly by topical (P < 0.0001) and oral (P <0.001) administrations of Phyllanthus niruri by about 32.5% and 21.3% respectively. Conclusions: Both topical and oral administrations of ethanolic extract of Phyllanthus niruri are found to reverse dexamethasone suppressed burn wound healing.

AB - Objective: To evaluate the effect of ethanolic extract of Phyllanthus niruri. Linn (Euphorbiaceae) on experimentally induced burn wound model in rats and to evaluate whether it reverses the wound healing in steroid suppressed rats. Methods: Two models including burn wound model and dexamethasone suppressed burn wound model were used in the study. The formulations of ethanolic extract of Phyllanthus niruri were prepared in gum acacia at 8% and in ointment base at 10% and were administered orally (400 mg/kg) and externally respectively. The parameters studied were the wound contraction and the period of epithelialisation. Results: In burn wound model, oral and topical administration of Phyllanthus niruri did not show any significant effects in wound contraction and period of epithelialisation when compared to control. In dexamethasone suppressed burn wound model, wound contraction rate was increased significantly by topical (P < 0.001) and oral (P < 0.001) administrations of Phyllanthus niruri by about 47.57% and 26.16% respectively. Topical administration has shown significant (P < 0.05) enhancement of wound contraction than oral dosage form. Dexamethasone depressed epithelialisation period was reversed significantly by topical (P < 0.0001) and oral (P <0.001) administrations of Phyllanthus niruri by about 32.5% and 21.3% respectively. Conclusions: Both topical and oral administrations of ethanolic extract of Phyllanthus niruri are found to reverse dexamethasone suppressed burn wound healing.

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