Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl4induced hepatotoxic rats

A. P. Manjrekar, V. Jisha, P. P. Bag, B. Adhikary, M. M. Pai, Anupama Hegde, M. Nandini

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Phyllanthus niruri extract is extensively used in treating liver ailments. Effects of aqueous extract of P. niruri on liver, kidney and testes of CCl4induced hepatotoxic rats were studied. High levels of malondialdehyde (MDA) were observed in the CCl4test group with significant reduction of MDA levels in all groups on P. niruri extract administration. Highest levels of glutathione (GSH) were found in P. niruri group. Activities of alanine transaminase, aspartate transaminase and alkaline phosphatase enzymes were significantly reduced in the curative group (P. niruri treatment after CCl4injection). Histopathology of liver showed lesser degree of inflammation in all P. niruri treated groups while the renal and seminiferous tubules showed eosinophilic protein casts with signs of tubular damage and degeneration. Testes also showed decreased amount of mature spermatozoa. The results suggest that P. niruri has anti-oxidant and hepato-protective activity with associated deleterious effects on kidney and testes.

Original languageEnglish
Pages (from-to)514-520
Number of pages7
JournalIndian Journal of Experimental Biology
Volume46
Issue number7
Publication statusPublished - 01-07-2008

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Phyllanthus
Testis
Malondialdehyde
Kidney
Liver
Seminiferous Tubules
Aspartate Aminotransferases
Alanine Transaminase
Oxidants
Glutathione
Alkaline Phosphatase
Spermatozoa
Inflammation
Enzymes
Proteins

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "Phyllanthus niruri extract is extensively used in treating liver ailments. Effects of aqueous extract of P. niruri on liver, kidney and testes of CCl4induced hepatotoxic rats were studied. High levels of malondialdehyde (MDA) were observed in the CCl4test group with significant reduction of MDA levels in all groups on P. niruri extract administration. Highest levels of glutathione (GSH) were found in P. niruri group. Activities of alanine transaminase, aspartate transaminase and alkaline phosphatase enzymes were significantly reduced in the curative group (P. niruri treatment after CCl4injection). Histopathology of liver showed lesser degree of inflammation in all P. niruri treated groups while the renal and seminiferous tubules showed eosinophilic protein casts with signs of tubular damage and degeneration. Testes also showed decreased amount of mature spermatozoa. The results suggest that P. niruri has anti-oxidant and hepato-protective activity with associated deleterious effects on kidney and testes.",
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Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl4induced hepatotoxic rats. / Manjrekar, A. P.; Jisha, V.; Bag, P. P.; Adhikary, B.; Pai, M. M.; Hegde, Anupama; Nandini, M.

In: Indian Journal of Experimental Biology, Vol. 46, No. 7, 01.07.2008, p. 514-520.

Research output: Contribution to journalArticle

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AU - Manjrekar, A. P.

AU - Jisha, V.

AU - Bag, P. P.

AU - Adhikary, B.

AU - Pai, M. M.

AU - Hegde, Anupama

AU - Nandini, M.

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AB - Phyllanthus niruri extract is extensively used in treating liver ailments. Effects of aqueous extract of P. niruri on liver, kidney and testes of CCl4induced hepatotoxic rats were studied. High levels of malondialdehyde (MDA) were observed in the CCl4test group with significant reduction of MDA levels in all groups on P. niruri extract administration. Highest levels of glutathione (GSH) were found in P. niruri group. Activities of alanine transaminase, aspartate transaminase and alkaline phosphatase enzymes were significantly reduced in the curative group (P. niruri treatment after CCl4injection). Histopathology of liver showed lesser degree of inflammation in all P. niruri treated groups while the renal and seminiferous tubules showed eosinophilic protein casts with signs of tubular damage and degeneration. Testes also showed decreased amount of mature spermatozoa. The results suggest that P. niruri has anti-oxidant and hepato-protective activity with associated deleterious effects on kidney and testes.

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