Effect of physical activity on insulin resistance, inflammation and oxidative stress in diabetes mellitus

Vighnesh Vetrivel Venkatasamy, Sandeep Pericherla, Sachin Manthuruthil, Shikha Mishra, Ram Hanno

Research output: Contribution to journalReview article

17 Citations (Scopus)


Diabetes Mellitus is a growing health concern projected to affect 366 million people worldwide by around 2030. Multiple approaches to address this health concern are documented; amongst which increased the habitual physical activity has been shown to be beneficial. Various mechanisms demonstrated show improvement of cellular insulin sensitivity. The interplay between insulin sensitivity and insulin resistance plays a key role in development and persistence of the diabetic state, which can be directly linked to the levels of physical activity. Regulation of adiponectin and leptin levels are also linked to physical activity via reduction of central obesity. Inflammatory markers, free radical reduction and up-regulation of physiological antioxidant processes are also observed in subjects with increased physical activity schedules, all of which play a significant role in the pathogenesis of Diabetes Mellitus.

Original languageEnglish
Pages (from-to)1764-1766
Number of pages3
JournalJournal of Clinical and Diagnostic Research
Issue number8
Publication statusPublished - 01-08-2013
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Clinical Biochemistry

Cite this