Effect of prenatal stress on expression of glutathione system in neonatal rat brain

Sudhanshu Sahu, Sampath Madhyastha, Gayathri Rao

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

AIM: Prenatal stress is known to adversely affect the fetal brain development and also neuronal loss. The mechanism(s) associated with prenatal stress induced developmental neurotoxicity remains obscure. Few studies point to the glutathione (GSH) antioxidant system which is an important molecular target for this toxicant. Hence the present study investigates the effect of prenatal stress on glutathione system in neonatal rat brain. MATERIAL and METHODS: Three to four months old pregnant Wistar rats were subjected to restraint stress during early or late gestational period.The offspring were sacrificed on 40th day and their brain homogenate was subjected to antioxidant studies. The serum corticosterone and adrenal ascorbic acid levels were also estimated from offspring. RESULTS: The prenatal stress has resulted in an increase in the serum corticosterone and reduced adrenal ascorbic acid levels in neonatal pups. Prenatal stress during early or late gestation life showed reduced glutathione, glutathione reductase (GSSG-Rd) and superoxide dismutase (SOD) activity in offspring brain homogenate. CONCLUSION: These data suggest that stress during early or late gestation period affect glutathione system in developing neonatal rat brain, which is associated with elevated serum corticosterone and reduced adrenal ascorbic acid levels.

Original languageEnglish
Pages (from-to)576-582
Number of pages7
JournalTurkish Neurosurgery
Volume22
Issue number5
DOIs
Publication statusPublished - 01-01-2012

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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