Effect of propranolol and nifedipine on maximal electroshock-induced seizures in mice: Individually and in combination

S. S. Raju, H. N. Gopalakrishna, N. Venkatadri

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A comparative effect of propranolol and nifedipine administered individually and in combination at graded dose levels; and that of phenytoin at 30 mg kg-1 on maximal electroshock (MES)-induced seizure in mice was investigated. Propranolol in doses of 10 mg kg-1 and 20 mg kg-1, and nifedipine in doses of 8 mg kg-1 and 16 mg kg-1 significantly modified MES activity. Propranolol (40 mg kg-1), and a combination of propranolol (20 mg kg-1) and nifedipine (8 mg kg-1), produced antiMES activity, which was comparable to that of phenytoin (30 mg kg-1). In mice treated with propranolol and nifedipine combination, the tonic flexor and tonic extensor phase ratios (F/E ratio) were significantly higher than individual drug responses. Our findings suggest that a combination of propranolol and nifedipine has either synergistic or an additive effect in controlling MES-induced seizures in mice.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalPharmacological Research
Issue number6
Publication statusPublished - 01-01-1998
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Pharmacology

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