Effect of Punica granatum peel aqueous extract on normal and dexamethasone suppressed wound healing in wistar rats

Shalini Adiga, Prakash Tomar, R. R. Rajput

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8 Citations (Scopus)

Abstract

Pomegranate (Punica granatum) is an ancient fruit used in various systems of medicine for a variety of ailments. Objective of the study was to determine wound healing effect of aqueous extract of Punica granatum peel on normal and dexamethasone suppressed wounds in wistar rats. Three wound models viz. incision, excision and dead space wounds were used in this study. The parameters studied were breaking strength in case of incision wounds, epithelialization and wound contraction in case of excision wound and granulation tissue dry weight, breaking strength and hydroxyproline content in case of dead space wound. Aqueous extract of Punica granatum peel treated groups (100 mg/kg and 50 mg/kg) showed significant (P<0.05) improvement in incision and granulation tissue breaking strength and hydroxylproline content as compared to control. Co administration of aqueous extract of Punica granatum peel at 100 mg/kg with dexamethasone had significantly (P<0.05) improved the incision wound, granulation tissue breaking strength and hydroxyproline content as compared to dexamethasone alone treated group. There was significant decrease (P<0.05) in epithelization period and significant improvement in percentage of wound contraction with aqueous extract of Punica granatum peel as compared to control group and has effectively reversed the effects of dexamethasone (p<0.05). In this study, aqueous extract of Punica granatum peel has shown to posses wound healing property and it effectively reverses the dexamethasone suppressed wound healing in all the three wound models in wistar rats.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume5
Issue number2
Publication statusPublished - 01-11-2010

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Punicaceae
Wound Healing
Dexamethasone
Wistar Rats
Wounds and Injuries
Granulation Tissue
Hydroxyproline
Re-Epithelialization
Systems Analysis
Fruit
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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abstract = "Pomegranate (Punica granatum) is an ancient fruit used in various systems of medicine for a variety of ailments. Objective of the study was to determine wound healing effect of aqueous extract of Punica granatum peel on normal and dexamethasone suppressed wounds in wistar rats. Three wound models viz. incision, excision and dead space wounds were used in this study. The parameters studied were breaking strength in case of incision wounds, epithelialization and wound contraction in case of excision wound and granulation tissue dry weight, breaking strength and hydroxyproline content in case of dead space wound. Aqueous extract of Punica granatum peel treated groups (100 mg/kg and 50 mg/kg) showed significant (P<0.05) improvement in incision and granulation tissue breaking strength and hydroxylproline content as compared to control. Co administration of aqueous extract of Punica granatum peel at 100 mg/kg with dexamethasone had significantly (P<0.05) improved the incision wound, granulation tissue breaking strength and hydroxyproline content as compared to dexamethasone alone treated group. There was significant decrease (P<0.05) in epithelization period and significant improvement in percentage of wound contraction with aqueous extract of Punica granatum peel as compared to control group and has effectively reversed the effects of dexamethasone (p<0.05). In this study, aqueous extract of Punica granatum peel has shown to posses wound healing property and it effectively reverses the dexamethasone suppressed wound healing in all the three wound models in wistar rats.",
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