Effect of recrystallization on size, shape, polymorph and dissolution of carbamazepine

R. Mahalaxmi, Ravikumar [No Value], S. Pandey, A. Shirwaikar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The recrystallization of carbamazepine was done by using two solvents and at different cooling conditions. The solvent and cooling conditions could modify the size, shape, polymorph and thereby the dissolution of original drug. The crystal shape of original carbamazepine was flaky or thin plate like. In the present work carbamazepine crystals were modified by using ethanol and acetone under four different cooling conditions. DSC study showed a change in the polymorphs under different conditions of cooling. The samples recrystallized from ethanol and acetone solutions as well as the original CBZ samples exhibited identical IR spectra, indicating that there was no change at the molecular level. A study indicated that the size, shape and the type of polymorphs in the sample effect its dissolution behaviour.
Original languageEnglish
Pages (from-to)725-732
Number of pages8
JournalInternational Journal of PharmTech Research
Volume1
Issue number3
Publication statusPublished - 2009

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Carbamazepine
Acetone
Ethanol

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Mahalaxmi, R. ; [No Value], Ravikumar ; Pandey, S. ; Shirwaikar, A. / Effect of recrystallization on size, shape, polymorph and dissolution of carbamazepine. In: International Journal of PharmTech Research. 2009 ; Vol. 1, No. 3. pp. 725-732.
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abstract = "The recrystallization of carbamazepine was done by using two solvents and at different cooling conditions. The solvent and cooling conditions could modify the size, shape, polymorph and thereby the dissolution of original drug. The crystal shape of original carbamazepine was flaky or thin plate like. In the present work carbamazepine crystals were modified by using ethanol and acetone under four different cooling conditions. DSC study showed a change in the polymorphs under different conditions of cooling. The samples recrystallized from ethanol and acetone solutions as well as the original CBZ samples exhibited identical IR spectra, indicating that there was no change at the molecular level. A study indicated that the size, shape and the type of polymorphs in the sample effect its dissolution behaviour.",
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note = "Cited By :5 Export Date: 10 November 2017 Correspondence Address: Mahalaxmi, R.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India; email: mahalaxmi.rathnanand@gmail.com Chemicals/CAS: acetone, 67-64-1; alcohol, 64-17-5; carbamazepine, 298-46-4, 8047-84-5 Manufacturers: Amoli Organics, India References: Melia, C.D., Davis, S.S., Review article: Mechanisms of drug release from tablets and capsules I: Disintegration (1989) Alimentary Pharmacology & Therapeutics, 3, pp. 223-232; Dominic, H., Josemir, W.S., (2006) Cost-effectiveness of carbamazepine in epilepsy, 6, pp. 13-18. , Expert Review of Pharmacoeconomics & Outcomes Research; Seetharam, M.N., Pellock, J.M., Risk-benefit assessment of carbamazepine in children (1991) Drug Saf, 6, pp. 148-158; Leppik, I.E., Metabolism of antiepileptic medication: Newborn to elderly (1992) Epilepsia, 33, pp. S32-S40; Garti, N., Tibika, E., Habit modification and nitrofurantoin crystallized from formic acid mixtures (1980) Drug DevIndPharm, 6, pp. 379-398; Rasenack BN, Muller BW. Physical Characterization Of Pharmaceutical Solids, Marcel Decker Inc, Newyork , 2002: PDI-36; Yoshiaki, A., Toshiyuki, N., Hirofumi, T., Tomoaki, H., Yoji, I., Characterization of Polymorphs of Tranilast Anhydrate And Tranilast Monohydrate When Crystallized By Two Solvent Change Spherical Crystallization Techniques Psychiatric adverse events in patients with epilepsy and learning disabilities taking levetiracetam (2004) Seizure, 13, pp. 55-57; Ravin, L.J., Radebaugh, G.W., (1990) Remington's Pharmaceutical Science, pp. 1440-1443. , Mack publishing company, U.S.A, 18th Edn; Masuda, K., Ashraful Islam, S.M., Parvin, A., Mohiuddin Abdul, Q., Controlled Release of Naproxen Sodium from Eudragit RS 100 Transdermal Film, Dhaka University (2004) Journal of Pharmaceutical Sciences, p. 3",
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Effect of recrystallization on size, shape, polymorph and dissolution of carbamazepine. / Mahalaxmi, R.; [No Value], Ravikumar; Pandey, S.; Shirwaikar, A.

In: International Journal of PharmTech Research, Vol. 1, No. 3, 2009, p. 725-732.

Research output: Contribution to journalArticle

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AU - Mahalaxmi, R.

AU - [No Value], Ravikumar

AU - Pandey, S.

AU - Shirwaikar, A.

N1 - Cited By :5 Export Date: 10 November 2017 Correspondence Address: Mahalaxmi, R.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India; email: mahalaxmi.rathnanand@gmail.com Chemicals/CAS: acetone, 67-64-1; alcohol, 64-17-5; carbamazepine, 298-46-4, 8047-84-5 Manufacturers: Amoli Organics, India References: Melia, C.D., Davis, S.S., Review article: Mechanisms of drug release from tablets and capsules I: Disintegration (1989) Alimentary Pharmacology & Therapeutics, 3, pp. 223-232; Dominic, H., Josemir, W.S., (2006) Cost-effectiveness of carbamazepine in epilepsy, 6, pp. 13-18. , Expert Review of Pharmacoeconomics & Outcomes Research; Seetharam, M.N., Pellock, J.M., Risk-benefit assessment of carbamazepine in children (1991) Drug Saf, 6, pp. 148-158; Leppik, I.E., Metabolism of antiepileptic medication: Newborn to elderly (1992) Epilepsia, 33, pp. S32-S40; Garti, N., Tibika, E., Habit modification and nitrofurantoin crystallized from formic acid mixtures (1980) Drug DevIndPharm, 6, pp. 379-398; Rasenack BN, Muller BW. Physical Characterization Of Pharmaceutical Solids, Marcel Decker Inc, Newyork , 2002: PDI-36; Yoshiaki, A., Toshiyuki, N., Hirofumi, T., Tomoaki, H., Yoji, I., Characterization of Polymorphs of Tranilast Anhydrate And Tranilast Monohydrate When Crystallized By Two Solvent Change Spherical Crystallization Techniques Psychiatric adverse events in patients with epilepsy and learning disabilities taking levetiracetam (2004) Seizure, 13, pp. 55-57; Ravin, L.J., Radebaugh, G.W., (1990) Remington's Pharmaceutical Science, pp. 1440-1443. , Mack publishing company, U.S.A, 18th Edn; Masuda, K., Ashraful Islam, S.M., Parvin, A., Mohiuddin Abdul, Q., Controlled Release of Naproxen Sodium from Eudragit RS 100 Transdermal Film, Dhaka University (2004) Journal of Pharmaceutical Sciences, p. 3

PY - 2009

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N2 - The recrystallization of carbamazepine was done by using two solvents and at different cooling conditions. The solvent and cooling conditions could modify the size, shape, polymorph and thereby the dissolution of original drug. The crystal shape of original carbamazepine was flaky or thin plate like. In the present work carbamazepine crystals were modified by using ethanol and acetone under four different cooling conditions. DSC study showed a change in the polymorphs under different conditions of cooling. The samples recrystallized from ethanol and acetone solutions as well as the original CBZ samples exhibited identical IR spectra, indicating that there was no change at the molecular level. A study indicated that the size, shape and the type of polymorphs in the sample effect its dissolution behaviour.

AB - The recrystallization of carbamazepine was done by using two solvents and at different cooling conditions. The solvent and cooling conditions could modify the size, shape, polymorph and thereby the dissolution of original drug. The crystal shape of original carbamazepine was flaky or thin plate like. In the present work carbamazepine crystals were modified by using ethanol and acetone under four different cooling conditions. DSC study showed a change in the polymorphs under different conditions of cooling. The samples recrystallized from ethanol and acetone solutions as well as the original CBZ samples exhibited identical IR spectra, indicating that there was no change at the molecular level. A study indicated that the size, shape and the type of polymorphs in the sample effect its dissolution behaviour.

M3 - Article

VL - 1

SP - 725

EP - 732

JO - International Journal of PharmTech Research

JF - International Journal of PharmTech Research

SN - 0974-4304

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ER -