Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice

Vipan Kumar Parihar, K. R. Prabhakar, Veeresh P. Veerapur, M. Sudheer Kumar, Y. Rosi Reddy, Ravi Joshi, M. K. Unnikrishnan, C. Mallikarjuna Rao

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Abstract

The radio-protective ability of sesamol (SM) at various doses viz., 0, 10, 25, 40, 50, 70 and 100 mg/kg bw, administered intraperitoneally 30 min prior to 9.5 Gy whole-body γ-irradiation was studied in Swiss albino mice. Radiation toxicity and mortality were observed during a period of 30 days and the percentage mortality was calculated. SM pretreatment with 50 mg/kg bw was found to be the most effective dose in maintaining body weight and in reducing the percentage mortality, while 100 mg/kg bw was found to be more effective in maintaining the spleen index and in stimulation of endogenous spleen colony-forming units. Pretreatment with SM (50 mg/kg bw) in mice irradiated with 15 Gy significantly reduced dead, inflammatory, mitotic and goblet cells in irradiated jejunum. SM at 50 mg/kg bw also increased crypt cells, maintained villus height, and prevented mucosal erosion. Nuclear enlargement in epithelial cells was found less in SM-treated mice compared with the irradiated control. The radiation-induced decrease in endogenous antioxidant enzymes (GSH, GST, catalase) and the increase in lipid peroxidation were also reduced by pretreatment with SM [50 and 100 mg/kg bw] at all monitored post-irradiation intervals. There was no protection at a dose less than 25 mg/kg bw.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume611
Issue number1-2
DOIs
Publication statusPublished - 10-12-2006

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Radiation
Mortality
Spleen
Goblet Cells
Whole-Body Irradiation
Jejunum
Radio
Catalase
Lipid Peroxidation
sesamol
Stem Cells
Antioxidants
Epithelial Cells
Body Weight
Enzymes

All Science Journal Classification (ASJC) codes

  • Health, Toxicology and Mutagenesis
  • Genetics

Cite this

Parihar, Vipan Kumar ; Prabhakar, K. R. ; Veerapur, Veeresh P. ; Kumar, M. Sudheer ; Reddy, Y. Rosi ; Joshi, Ravi ; Unnikrishnan, M. K. ; Rao, C. Mallikarjuna. / Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice. In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 2006 ; Vol. 611, No. 1-2. pp. 9-16.
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Parihar, VK, Prabhakar, KR, Veerapur, VP, Kumar, MS, Reddy, YR, Joshi, R, Unnikrishnan, MK & Rao, CM 2006, 'Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice', Mutation Research - Genetic Toxicology and Environmental Mutagenesis, vol. 611, no. 1-2, pp. 9-16. https://doi.org/10.1016/j.mrgentox.2006.06.037

Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice. / Parihar, Vipan Kumar; Prabhakar, K. R.; Veerapur, Veeresh P.; Kumar, M. Sudheer; Reddy, Y. Rosi; Joshi, Ravi; Unnikrishnan, M. K.; Rao, C. Mallikarjuna.

In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Vol. 611, No. 1-2, 10.12.2006, p. 9-16.

Research output: Contribution to journalArticle

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T1 - Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice

AU - Parihar, Vipan Kumar

AU - Prabhakar, K. R.

AU - Veerapur, Veeresh P.

AU - Kumar, M. Sudheer

AU - Reddy, Y. Rosi

AU - Joshi, Ravi

AU - Unnikrishnan, M. K.

AU - Rao, C. Mallikarjuna

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N2 - The radio-protective ability of sesamol (SM) at various doses viz., 0, 10, 25, 40, 50, 70 and 100 mg/kg bw, administered intraperitoneally 30 min prior to 9.5 Gy whole-body γ-irradiation was studied in Swiss albino mice. Radiation toxicity and mortality were observed during a period of 30 days and the percentage mortality was calculated. SM pretreatment with 50 mg/kg bw was found to be the most effective dose in maintaining body weight and in reducing the percentage mortality, while 100 mg/kg bw was found to be more effective in maintaining the spleen index and in stimulation of endogenous spleen colony-forming units. Pretreatment with SM (50 mg/kg bw) in mice irradiated with 15 Gy significantly reduced dead, inflammatory, mitotic and goblet cells in irradiated jejunum. SM at 50 mg/kg bw also increased crypt cells, maintained villus height, and prevented mucosal erosion. Nuclear enlargement in epithelial cells was found less in SM-treated mice compared with the irradiated control. The radiation-induced decrease in endogenous antioxidant enzymes (GSH, GST, catalase) and the increase in lipid peroxidation were also reduced by pretreatment with SM [50 and 100 mg/kg bw] at all monitored post-irradiation intervals. There was no protection at a dose less than 25 mg/kg bw.

AB - The radio-protective ability of sesamol (SM) at various doses viz., 0, 10, 25, 40, 50, 70 and 100 mg/kg bw, administered intraperitoneally 30 min prior to 9.5 Gy whole-body γ-irradiation was studied in Swiss albino mice. Radiation toxicity and mortality were observed during a period of 30 days and the percentage mortality was calculated. SM pretreatment with 50 mg/kg bw was found to be the most effective dose in maintaining body weight and in reducing the percentage mortality, while 100 mg/kg bw was found to be more effective in maintaining the spleen index and in stimulation of endogenous spleen colony-forming units. Pretreatment with SM (50 mg/kg bw) in mice irradiated with 15 Gy significantly reduced dead, inflammatory, mitotic and goblet cells in irradiated jejunum. SM at 50 mg/kg bw also increased crypt cells, maintained villus height, and prevented mucosal erosion. Nuclear enlargement in epithelial cells was found less in SM-treated mice compared with the irradiated control. The radiation-induced decrease in endogenous antioxidant enzymes (GSH, GST, catalase) and the increase in lipid peroxidation were also reduced by pretreatment with SM [50 and 100 mg/kg bw] at all monitored post-irradiation intervals. There was no protection at a dose less than 25 mg/kg bw.

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