Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice

Vipan Kumar Parihar, K. R. Prabhakar, Veeresh P. Veerapur, M. Sudheer Kumar, Y. Rosi Reddy, Ravi Joshi, M. K. Unnikrishnan, C. Mallikarjuna Rao

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Abstract

The radio-protective ability of sesamol (SM) at various doses viz., 0, 10, 25, 40, 50, 70 and 100 mg/kg bw, administered intraperitoneally 30 min prior to 9.5 Gy whole-body γ-irradiation was studied in Swiss albino mice. Radiation toxicity and mortality were observed during a period of 30 days and the percentage mortality was calculated. SM pretreatment with 50 mg/kg bw was found to be the most effective dose in maintaining body weight and in reducing the percentage mortality, while 100 mg/kg bw was found to be more effective in maintaining the spleen index and in stimulation of endogenous spleen colony-forming units. Pretreatment with SM (50 mg/kg bw) in mice irradiated with 15 Gy significantly reduced dead, inflammatory, mitotic and goblet cells in irradiated jejunum. SM at 50 mg/kg bw also increased crypt cells, maintained villus height, and prevented mucosal erosion. Nuclear enlargement in epithelial cells was found less in SM-treated mice compared with the irradiated control. The radiation-induced decrease in endogenous antioxidant enzymes (GSH, GST, catalase) and the increase in lipid peroxidation were also reduced by pretreatment with SM [50 and 100 mg/kg bw] at all monitored post-irradiation intervals. There was no protection at a dose less than 25 mg/kg bw.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume611
Issue number1-2
DOIs
Publication statusPublished - 10-12-2006

All Science Journal Classification (ASJC) codes

  • Health, Toxicology and Mutagenesis
  • Genetics

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    Parihar, V. K., Prabhakar, K. R., Veerapur, V. P., Kumar, M. S., Reddy, Y. R., Joshi, R., Unnikrishnan, M. K., & Rao, C. M. (2006). Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 611(1-2), 9-16. https://doi.org/10.1016/j.mrgentox.2006.06.037