Effect of tolmetin and its copper complex on wound healing

S. N. Somayaji; A. P. Jacob; K. L. Bairy

Effect of tolmetin and its copper complex on wound healing

S. N. Somayaji, A. P. Jacob, K. L. Bairy

Research output: Contribution to journal › Article › peer-review

Abstract

Dose matched comparison between copper complex of tolmetin (Tol-Cu) and tolmetin (Tol) was carried out in male albino rats bearing either sutured incision, dead space or excision wounds. Results showed that Tol significantly decreased tensile strength of incision and dead space wound. This effect was totally reversed by copper present in Tol-Cu. Tol-Cu shared the significant suppressant effect of Tol on granulation formation and its collagen content. Tol suppressed wound contraction and epithelialization and copper complex of Tol antagonised the suppressant effect of Tol on wound contraction and epithelialization.

Original language	English
Pages (from-to)	201-204
Number of pages	4
Journal	Indian Journal of Experimental Biology
Volume	33
Issue number	3
Publication status	Published - 01-01-1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Bioengineering

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abstract = "Dose matched comparison between copper complex of tolmetin (Tol-Cu) and tolmetin (Tol) was carried out in male albino rats bearing either sutured incision, dead space or excision wounds. Results showed that Tol significantly decreased tensile strength of incision and dead space wound. This effect was totally reversed by copper present in Tol-Cu. Tol-Cu shared the significant suppressant effect of Tol on granulation formation and its collagen content. Tol suppressed wound contraction and epithelialization and copper complex of Tol antagonised the suppressant effect of Tol on wound contraction and epithelialization.",

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AU - Jacob, A. P.

AU - Bairy, K. L.

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N2 - Dose matched comparison between copper complex of tolmetin (Tol-Cu) and tolmetin (Tol) was carried out in male albino rats bearing either sutured incision, dead space or excision wounds. Results showed that Tol significantly decreased tensile strength of incision and dead space wound. This effect was totally reversed by copper present in Tol-Cu. Tol-Cu shared the significant suppressant effect of Tol on granulation formation and its collagen content. Tol suppressed wound contraction and epithelialization and copper complex of Tol antagonised the suppressant effect of Tol on wound contraction and epithelialization.

AB - Dose matched comparison between copper complex of tolmetin (Tol-Cu) and tolmetin (Tol) was carried out in male albino rats bearing either sutured incision, dead space or excision wounds. Results showed that Tol significantly decreased tensile strength of incision and dead space wound. This effect was totally reversed by copper present in Tol-Cu. Tol-Cu shared the significant suppressant effect of Tol on granulation formation and its collagen content. Tol suppressed wound contraction and epithelialization and copper complex of Tol antagonised the suppressant effect of Tol on wound contraction and epithelialization.

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Effect of tolmetin and its copper complex on wound healing

Abstract

All Science Journal Classification (ASJC) codes

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