Abstract
Dose matched comparison between copper complex of tolmetin (Tol-Cu) and tolmetin (Tol) was carried out in male albino rats bearing either sutured incision, dead space or excision wounds. Results showed that Tol significantly decreased tensile strength of incision and dead space wound. This effect was totally reversed by copper present in Tol-Cu. Tol-Cu shared the significant suppressant effect of Tol on granulation formation and its collagen content. Tol suppressed wound contraction and epithelialization and copper complex of Tol antagonised the suppressant effect of Tol on wound contraction and epithelialization.
| Original language | English |
|---|---|
| Pages (from-to) | 201-204 |
| Number of pages | 4 |
| Journal | Indian Journal of Experimental Biology |
| Volume | 33 |
| Issue number | 3 |
| Publication status | Published - 01-01-1995 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Bioengineering
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Effect of tolmetin and its copper complex on wound healing. / Somayaji, S. N.; Jacob, A. P.; Bairy, K. L.
In: Indian Journal of Experimental Biology, Vol. 33, No. 3, 01.01.1995, p. 201-204.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of tolmetin and its copper complex on wound healing
AU - Somayaji, S. N.
AU - Jacob, A. P.
AU - Bairy, K. L.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Dose matched comparison between copper complex of tolmetin (Tol-Cu) and tolmetin (Tol) was carried out in male albino rats bearing either sutured incision, dead space or excision wounds. Results showed that Tol significantly decreased tensile strength of incision and dead space wound. This effect was totally reversed by copper present in Tol-Cu. Tol-Cu shared the significant suppressant effect of Tol on granulation formation and its collagen content. Tol suppressed wound contraction and epithelialization and copper complex of Tol antagonised the suppressant effect of Tol on wound contraction and epithelialization.
AB - Dose matched comparison between copper complex of tolmetin (Tol-Cu) and tolmetin (Tol) was carried out in male albino rats bearing either sutured incision, dead space or excision wounds. Results showed that Tol significantly decreased tensile strength of incision and dead space wound. This effect was totally reversed by copper present in Tol-Cu. Tol-Cu shared the significant suppressant effect of Tol on granulation formation and its collagen content. Tol suppressed wound contraction and epithelialization and copper complex of Tol antagonised the suppressant effect of Tol on wound contraction and epithelialization.
UR - http://www.scopus.com/inward/record.url?scp=0028957512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028957512&partnerID=8YFLogxK
M3 - Article
VL - 33
SP - 201
EP - 204
JO - Journal of scientific & industrial research. C. Biological sciences
JF - Journal of scientific & industrial research. C. Biological sciences
SN - 0019-5189
IS - 3
ER -