Effect of topical phenytoin on burn wound healing in rats

K. Meena Kumari, A. V. Mohan, B. Sharath, S. N. Somayaji, K. L. Bairy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To evaluate the effect of phenytoin on burn wounds and to compare the effect of the combination of topical phenytoin preparation in dexamethasone treated burn wounds in rats, partial thickness thermal burn wounds were inflicted upon five groups of six rats each. Group I was assigned as control, Group II received the standard silver sulphadiazine, Group III was given topical phenytoin and Group IV received injection dexamethasone, Group V received the combination of the phenytoin and the dexamethasone. The parameters observed were epithelialization period, percentage of wound contraction and histopathological analysis as indicative of the process of healing. Phenytoin group showed significant improvement in burn wound contraction in comparison to standard silver sulphadiazine group, the combination group of topical phenytoin and dexamethasone also showed significant contraction compared to dexamethasone group. The period of epithelialization also decreased significantly in groups II, III and V. In conclusion, phenytoin promotes burn wound healing as evidenced by decrease in period of epithelialization and faster wound contraction.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalIndian Journal of Experimental Biology
Volume49
Issue number1
Publication statusPublished - 01-01-2011
Externally publishedYes

Fingerprint

Phenytoin
Wound Healing
Dexamethasone
Wounds and Injuries
Sulfadiazine
Silver
Re-Epithelialization
Hot Temperature
Control Groups
Injections

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology
  • Cell Biology

Cite this

Meena Kumari, K. ; Mohan, A. V. ; Sharath, B. ; Somayaji, S. N. ; Bairy, K. L. / Effect of topical phenytoin on burn wound healing in rats. In: Indian Journal of Experimental Biology. 2011 ; Vol. 49, No. 1. pp. 56-59.
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Effect of topical phenytoin on burn wound healing in rats. / Meena Kumari, K.; Mohan, A. V.; Sharath, B.; Somayaji, S. N.; Bairy, K. L.

In: Indian Journal of Experimental Biology, Vol. 49, No. 1, 01.01.2011, p. 56-59.

Research output: Contribution to journalArticle

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AU - Mohan, A. V.

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AU - Somayaji, S. N.

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AB - To evaluate the effect of phenytoin on burn wounds and to compare the effect of the combination of topical phenytoin preparation in dexamethasone treated burn wounds in rats, partial thickness thermal burn wounds were inflicted upon five groups of six rats each. Group I was assigned as control, Group II received the standard silver sulphadiazine, Group III was given topical phenytoin and Group IV received injection dexamethasone, Group V received the combination of the phenytoin and the dexamethasone. The parameters observed were epithelialization period, percentage of wound contraction and histopathological analysis as indicative of the process of healing. Phenytoin group showed significant improvement in burn wound contraction in comparison to standard silver sulphadiazine group, the combination group of topical phenytoin and dexamethasone also showed significant contraction compared to dexamethasone group. The period of epithelialization also decreased significantly in groups II, III and V. In conclusion, phenytoin promotes burn wound healing as evidenced by decrease in period of epithelialization and faster wound contraction.

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