Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats

Smita Shenoy, Raghu Murthy, Lalit Mohan, Amoolya Gowda, Venu Madhav Nelluri

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Poor wound healing is a complication of diabetes mellitus. Various agents have been used to promote wound healing in diabetic patients. Papain urea is used as a sloughing agent, whereas sodium fusidate and calcium mupirocin are used as topical antimicrobials for wounds in diabetics. Aims and Objective: To evaluate effect of topical sodium fusidate, calcium mupirocin, and papain-urea on wound healing in diabetic wistar rats. Materials and Methods: Incision and excision wound models were used. Each model had five groups of six rats each and one group was nondiabetic control. Diabetes was induced in the remaining four groups, one diabetic control, and three test groups in each model, using streptozotocin (30 mg/kg intraperitoneally). Wounds were made in diabetic rats with blood glucose levels of more than 250 mg/dL. Paraffin ointment base was applied to wounds of nondiabetic and diabetic control, whereas sodium fusidate, mupirocin, and papain-urea were applied topically to three test groups, respectively, in each model. Result: In sodium fusidate-treated group, there was a significant increase in breaking strength of incision wound, contraction rate, and hydroxyproline content of excision wound as compared to diabetic control group. There was significant decrease in period of epithelization in sodium fusidate-treated group compared to diabetic control group. There was no significant alteration in wound healing by mupirocin and papain-urea. Conclusion: Topical application of sodium fusidate promoted wound healing in diabetic rats.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalNational Journal of Physiology, Pharmacy and Pharmacology
Volume6
Issue number3
DOIs
Publication statusPublished - 01-01-2016

Fingerprint

Mupirocin
Fusidic Acid
Wound Healing
Wistar Rats
Papain
Calcium
Urea
Wounds and Injuries
Ointment Bases
Control Groups
Hydroxyproline
Diabetes Complications
Streptozocin
Paraffin
Blood Glucose

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{028324b7cba44455be55aeb54b201649,
title = "Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats",
abstract = "Background: Poor wound healing is a complication of diabetes mellitus. Various agents have been used to promote wound healing in diabetic patients. Papain urea is used as a sloughing agent, whereas sodium fusidate and calcium mupirocin are used as topical antimicrobials for wounds in diabetics. Aims and Objective: To evaluate effect of topical sodium fusidate, calcium mupirocin, and papain-urea on wound healing in diabetic wistar rats. Materials and Methods: Incision and excision wound models were used. Each model had five groups of six rats each and one group was nondiabetic control. Diabetes was induced in the remaining four groups, one diabetic control, and three test groups in each model, using streptozotocin (30 mg/kg intraperitoneally). Wounds were made in diabetic rats with blood glucose levels of more than 250 mg/dL. Paraffin ointment base was applied to wounds of nondiabetic and diabetic control, whereas sodium fusidate, mupirocin, and papain-urea were applied topically to three test groups, respectively, in each model. Result: In sodium fusidate-treated group, there was a significant increase in breaking strength of incision wound, contraction rate, and hydroxyproline content of excision wound as compared to diabetic control group. There was significant decrease in period of epithelization in sodium fusidate-treated group compared to diabetic control group. There was no significant alteration in wound healing by mupirocin and papain-urea. Conclusion: Topical application of sodium fusidate promoted wound healing in diabetic rats.",
author = "Smita Shenoy and Raghu Murthy and Lalit Mohan and Amoolya Gowda and Nelluri, {Venu Madhav}",
year = "2016",
month = "1",
day = "1",
doi = "10.5455/njppp.2016.6.28012016115",
language = "English",
volume = "6",
pages = "209--214",
journal = "National Journal of Physiology, Pharmacy and Pharmacology",
issn = "2320-4672",
publisher = "Mrs Dipika Charan for MedScience Publishers",
number = "3",

}

Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats. / Shenoy, Smita; Murthy, Raghu; Mohan, Lalit; Gowda, Amoolya; Nelluri, Venu Madhav.

In: National Journal of Physiology, Pharmacy and Pharmacology, Vol. 6, No. 3, 01.01.2016, p. 209-214.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats

AU - Shenoy, Smita

AU - Murthy, Raghu

AU - Mohan, Lalit

AU - Gowda, Amoolya

AU - Nelluri, Venu Madhav

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Poor wound healing is a complication of diabetes mellitus. Various agents have been used to promote wound healing in diabetic patients. Papain urea is used as a sloughing agent, whereas sodium fusidate and calcium mupirocin are used as topical antimicrobials for wounds in diabetics. Aims and Objective: To evaluate effect of topical sodium fusidate, calcium mupirocin, and papain-urea on wound healing in diabetic wistar rats. Materials and Methods: Incision and excision wound models were used. Each model had five groups of six rats each and one group was nondiabetic control. Diabetes was induced in the remaining four groups, one diabetic control, and three test groups in each model, using streptozotocin (30 mg/kg intraperitoneally). Wounds were made in diabetic rats with blood glucose levels of more than 250 mg/dL. Paraffin ointment base was applied to wounds of nondiabetic and diabetic control, whereas sodium fusidate, mupirocin, and papain-urea were applied topically to three test groups, respectively, in each model. Result: In sodium fusidate-treated group, there was a significant increase in breaking strength of incision wound, contraction rate, and hydroxyproline content of excision wound as compared to diabetic control group. There was significant decrease in period of epithelization in sodium fusidate-treated group compared to diabetic control group. There was no significant alteration in wound healing by mupirocin and papain-urea. Conclusion: Topical application of sodium fusidate promoted wound healing in diabetic rats.

AB - Background: Poor wound healing is a complication of diabetes mellitus. Various agents have been used to promote wound healing in diabetic patients. Papain urea is used as a sloughing agent, whereas sodium fusidate and calcium mupirocin are used as topical antimicrobials for wounds in diabetics. Aims and Objective: To evaluate effect of topical sodium fusidate, calcium mupirocin, and papain-urea on wound healing in diabetic wistar rats. Materials and Methods: Incision and excision wound models were used. Each model had five groups of six rats each and one group was nondiabetic control. Diabetes was induced in the remaining four groups, one diabetic control, and three test groups in each model, using streptozotocin (30 mg/kg intraperitoneally). Wounds were made in diabetic rats with blood glucose levels of more than 250 mg/dL. Paraffin ointment base was applied to wounds of nondiabetic and diabetic control, whereas sodium fusidate, mupirocin, and papain-urea were applied topically to three test groups, respectively, in each model. Result: In sodium fusidate-treated group, there was a significant increase in breaking strength of incision wound, contraction rate, and hydroxyproline content of excision wound as compared to diabetic control group. There was significant decrease in period of epithelization in sodium fusidate-treated group compared to diabetic control group. There was no significant alteration in wound healing by mupirocin and papain-urea. Conclusion: Topical application of sodium fusidate promoted wound healing in diabetic rats.

UR - http://www.scopus.com/inward/record.url?scp=85006186564&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006186564&partnerID=8YFLogxK

U2 - 10.5455/njppp.2016.6.28012016115

DO - 10.5455/njppp.2016.6.28012016115

M3 - Article

VL - 6

SP - 209

EP - 214

JO - National Journal of Physiology, Pharmacy and Pharmacology

JF - National Journal of Physiology, Pharmacy and Pharmacology

SN - 2320-4672

IS - 3

ER -