Effect of trace metals on synthesis of exoproteins and exotoxins by Staphylococcus aureus.

K. G. Bhat, P. G. Shivananda

Research output: Contribution to journalArticle


Staphylococcus aureus did not grow in chemically defined medium completely free of trace metals. At low concentrations all the trace metals showed stimulating effect on growth and exoprotein production. Increasing concentrations of Ca2+ and Mg2+ were growth stimulatory whereas Co2+, Cu2+, Fe3+, Mn2+, Ni2+ and Zn2+ were inhibitory. The amount of exoprotein and haemolytic exotoxins produced in relation to final viable count increased with increasing concentrations of growth inhibitory trace metals whereas it decreased with increasing concentrations of Ca2+ and Mg2+. Trace metals did not show significant influence on amount of haemolytic exotoxins produced in relation to total exoproteins. The results indicate presence of a common regulatory mechanism for all types of exoproteins produced by S. aureus.

Original languageEnglish
Pages (from-to)416-419
Number of pages4
JournalIndian Journal of Experimental Biology
Issue number6
Publication statusPublished - 01-06-1995


All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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