Effect of treatment with 'nishamalaki' powder on glycemic control and markers of erythrocyte oxidative stress in diabetic rats compared to troglitazone

Guruprasad Rao, Surekha Bhat, S. Gurumadhva Rao, P. Gopalakrishna Bhat

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The 1:1 (w/w) mixture of powdered rhizome of Curcuma longa (turmeric) and the dried fruits of Emblica officinalis (Indian gooseberry) known as 'nishamalaki', described in traditional Indian medicine as a therapeutic agent in diabetes mellitus was studied for its effect on glycemic control and erythrocyte parameters of oxidative stress in rats with streptozotocin-induced diabetes mellitus in comparison with troglitazone, a thiazolidinedione compound known to possess antioxidant properties and the sulfonylurea drug, glyburide. Streptozotocin-induced diabetic rats were divided into the following treatment groups; nishamalaki powder treated (0.9 g/kg, NT group, n=12), troglitazone treated (36 mg/kg, TT group, n=12) and glyburide treated (4 mg/kg, GT group, n=12). The animals received the respective treatments for 30 days, at the end of which plasma glucose, glycated hemoglobin and erythrocyte parameters of oxidative stress were measured in all animals and the results compared with those of the untreated diabetic control (DC, n=12) and normal control (NC, n=12) rats. Nishamalaki treatment resulted in significant lowering of plasma glucose and glycated hemoglobin in diabetic rats (p<0.001 NT vs DC) comparable to that of the GT and TT groups. Erythrocyte membrane lipid peroxidation was lowered to a comparable extent by the three drugs (p<0.001 vs DC). NT rats showed greater improvement in erythrocyte reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity (both p<0.001 vs DC) than GT rats (p>0.05 vs DC for GSH and p<0.05 vs DC for GSH-Px) and this was comparable to the results of TT rats. Erythrocyte superoxide dismutase (SOD) activity was restored to a similar extent by the three drugs (p<0.01 vs DC). Glycemic control exerted by nishamalaki powder in diabetic rats is comparable to that of glyburide and troglitazone. Antioxidant protection offered by this preparation compares favourably with troglitazone and is greater than glyburide suggesting a role for this preparation in the management of diabetes mellitus.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume19
Issue number2
Publication statusPublished - 01-03-2013

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troglitazone
Powders
Oxidative Stress
Glyburide
Erythrocytes
Curcuma
Diabetes Mellitus
Glycosylated Hemoglobin A
Therapeutics
Antioxidants
Phyllanthus emblica
Ribes
Glucose
Rhizome
Experimental Diabetes Mellitus
Traditional Medicine
Streptozocin
Pharmaceutical Preparations
Superoxide Dismutase
Fruit

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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title = "Effect of treatment with 'nishamalaki' powder on glycemic control and markers of erythrocyte oxidative stress in diabetic rats compared to troglitazone",
abstract = "The 1:1 (w/w) mixture of powdered rhizome of Curcuma longa (turmeric) and the dried fruits of Emblica officinalis (Indian gooseberry) known as 'nishamalaki', described in traditional Indian medicine as a therapeutic agent in diabetes mellitus was studied for its effect on glycemic control and erythrocyte parameters of oxidative stress in rats with streptozotocin-induced diabetes mellitus in comparison with troglitazone, a thiazolidinedione compound known to possess antioxidant properties and the sulfonylurea drug, glyburide. Streptozotocin-induced diabetic rats were divided into the following treatment groups; nishamalaki powder treated (0.9 g/kg, NT group, n=12), troglitazone treated (36 mg/kg, TT group, n=12) and glyburide treated (4 mg/kg, GT group, n=12). The animals received the respective treatments for 30 days, at the end of which plasma glucose, glycated hemoglobin and erythrocyte parameters of oxidative stress were measured in all animals and the results compared with those of the untreated diabetic control (DC, n=12) and normal control (NC, n=12) rats. Nishamalaki treatment resulted in significant lowering of plasma glucose and glycated hemoglobin in diabetic rats (p<0.001 NT vs DC) comparable to that of the GT and TT groups. Erythrocyte membrane lipid peroxidation was lowered to a comparable extent by the three drugs (p<0.001 vs DC). NT rats showed greater improvement in erythrocyte reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity (both p<0.001 vs DC) than GT rats (p>0.05 vs DC for GSH and p<0.05 vs DC for GSH-Px) and this was comparable to the results of TT rats. Erythrocyte superoxide dismutase (SOD) activity was restored to a similar extent by the three drugs (p<0.01 vs DC). Glycemic control exerted by nishamalaki powder in diabetic rats is comparable to that of glyburide and troglitazone. Antioxidant protection offered by this preparation compares favourably with troglitazone and is greater than glyburide suggesting a role for this preparation in the management of diabetes mellitus.",
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Effect of treatment with 'nishamalaki' powder on glycemic control and markers of erythrocyte oxidative stress in diabetic rats compared to troglitazone. / Rao, Guruprasad; Bhat, Surekha; Gurumadhva Rao, S.; Gopalakrishna Bhat, P.

In: International Journal of Pharmaceutical Sciences Review and Research, Vol. 19, No. 2, 01.03.2013, p. 127-134.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of treatment with 'nishamalaki' powder on glycemic control and markers of erythrocyte oxidative stress in diabetic rats compared to troglitazone

AU - Rao, Guruprasad

AU - Bhat, Surekha

AU - Gurumadhva Rao, S.

AU - Gopalakrishna Bhat, P.

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N2 - The 1:1 (w/w) mixture of powdered rhizome of Curcuma longa (turmeric) and the dried fruits of Emblica officinalis (Indian gooseberry) known as 'nishamalaki', described in traditional Indian medicine as a therapeutic agent in diabetes mellitus was studied for its effect on glycemic control and erythrocyte parameters of oxidative stress in rats with streptozotocin-induced diabetes mellitus in comparison with troglitazone, a thiazolidinedione compound known to possess antioxidant properties and the sulfonylurea drug, glyburide. Streptozotocin-induced diabetic rats were divided into the following treatment groups; nishamalaki powder treated (0.9 g/kg, NT group, n=12), troglitazone treated (36 mg/kg, TT group, n=12) and glyburide treated (4 mg/kg, GT group, n=12). The animals received the respective treatments for 30 days, at the end of which plasma glucose, glycated hemoglobin and erythrocyte parameters of oxidative stress were measured in all animals and the results compared with those of the untreated diabetic control (DC, n=12) and normal control (NC, n=12) rats. Nishamalaki treatment resulted in significant lowering of plasma glucose and glycated hemoglobin in diabetic rats (p<0.001 NT vs DC) comparable to that of the GT and TT groups. Erythrocyte membrane lipid peroxidation was lowered to a comparable extent by the three drugs (p<0.001 vs DC). NT rats showed greater improvement in erythrocyte reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity (both p<0.001 vs DC) than GT rats (p>0.05 vs DC for GSH and p<0.05 vs DC for GSH-Px) and this was comparable to the results of TT rats. Erythrocyte superoxide dismutase (SOD) activity was restored to a similar extent by the three drugs (p<0.01 vs DC). Glycemic control exerted by nishamalaki powder in diabetic rats is comparable to that of glyburide and troglitazone. Antioxidant protection offered by this preparation compares favourably with troglitazone and is greater than glyburide suggesting a role for this preparation in the management of diabetes mellitus.

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