Effect of Tribulus terrestris on haloperidol-induced catalepsy in mice

B. S. Nishchal, S. Rai, M. N. Prabhu, Sheetal D. Ullal, S. Rajeswari, H. N. Gopalakrishna

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Haloperidol, an antipsychotic drug, leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture. In the present study we have attempted to evaluate the anticataleptic effect of Tribulus terrestris on haloperidol-induced catalepsy in albino mice. Mice were allocated to four groups, each group containing six animals. Both, the test drug, Tribulus terrestris and the standard drug trihexyphenidyl were uniformly suspended in 1% gum acacia solution. Catalepsy was induced in mice with haloperidol (1.0 mg/kg, intraperitoneally). The first group received the vehicle (10 ml/kg, orally), the second group received trihexyphenidyl (10 mg/kg, orally) and the remaining two groups received Tribulus terrestris (100, 200 mg/kg, orally). The animals were assessed after single and repeated dose administration for ten days, 30 min prior to haloperidol, using standard bar test. The result of the present study demonstrates Tribulus terrestris has a protective effect against haloperidol-induced catalepsy, which is comparable to the standard drug used for the same purpose. Our study indicates Tribulus terrestris can be used to prevent haloperidol-induced extrapyramidal side effects.

Original languageEnglish
Pages (from-to)564-567
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume76
Issue number6
Publication statusPublished - 01-01-2014

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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