Effect of tribulus terrestris on learning and memory in wistar rats

Natesh Prabhu, Sanjay Hadigal, D. Ullal Sheetal, D. S. Sushma, K. Ashok Shenoy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: The present study was designed to evaluate the effect of aqueous extract of fruits of Tribulus terrestris on learning and memory in rodents. Materials and Methods: Thirty wistar rats were divided in 5 groups of 6 rats each. Baseline values for the time taken to reach reward chamber (TRC) in the Hebb William Maze and transfer latency (TL) in the T-maze were recorded on Day 1. Mean of 5 sessions was calculated for each rat. Group I was normal control, group II piracetam standard, group III, IV and V received Tribulus terrestris orally at 100mg/kg, 200mg/kg and 400mg/kg respectively for 14 days. At the end of 14 days, each rat was tested for TRC and TL and compared with the control group. Results: Group IV showed a significant decrease in TRC when compared to group I in Hebb William Maze (p<0.0001). Group IV also showed a significant decrease in TL when compared to group I in T-maze (p<0.0001). Group III showed a significant decrease in TL when compared to group I in the T-maze (p=0.035), however there was no decrease in TRC in this group. Conclusions: The aqueous extract of fruits of Tribulus terrestris showed a dose dependent beneficial effect in learning and memory models in rats, with 200mg/kg being most beneficial.

Original languageEnglish
Pages (from-to)68-71
Number of pages4
JournalPharmacognosy Journal
Volume6
Issue number4
DOIs
Publication statusPublished - 01-01-2014

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Tribulus
Reward
Wistar Rats
Learning
Fruit
Piracetam
Control Groups
Rodentia
Transfer (Psychology)

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Prabhu, Natesh ; Hadigal, Sanjay ; Ullal Sheetal, D. ; Sushma, D. S. ; Ashok Shenoy, K. / Effect of tribulus terrestris on learning and memory in wistar rats. In: Pharmacognosy Journal. 2014 ; Vol. 6, No. 4. pp. 68-71.
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Effect of tribulus terrestris on learning and memory in wistar rats. / Prabhu, Natesh; Hadigal, Sanjay; Ullal Sheetal, D.; Sushma, D. S.; Ashok Shenoy, K.

In: Pharmacognosy Journal, Vol. 6, No. 4, 01.01.2014, p. 68-71.

Research output: Contribution to journalArticle

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