Effect of tribulus terrestris on learning and memory in wistar rats

Natesh Prabhu, Sanjay Hadigal, D. Ullal Sheetal, D. S. Sushma, K. Ashok Shenoy

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objectives: The present study was designed to evaluate the effect of aqueous extract of fruits of Tribulus terrestris on learning and memory in rodents. Materials and Methods: Thirty wistar rats were divided in 5 groups of 6 rats each. Baseline values for the time taken to reach reward chamber (TRC) in the Hebb William Maze and transfer latency (TL) in the T-maze were recorded on Day 1. Mean of 5 sessions was calculated for each rat. Group I was normal control, group II piracetam standard, group III, IV and V received Tribulus terrestris orally at 100mg/kg, 200mg/kg and 400mg/kg respectively for 14 days. At the end of 14 days, each rat was tested for TRC and TL and compared with the control group. Results: Group IV showed a significant decrease in TRC when compared to group I in Hebb William Maze (p<0.0001). Group IV also showed a significant decrease in TL when compared to group I in T-maze (p<0.0001). Group III showed a significant decrease in TL when compared to group I in the T-maze (p=0.035), however there was no decrease in TRC in this group. Conclusions: The aqueous extract of fruits of Tribulus terrestris showed a dose dependent beneficial effect in learning and memory models in rats, with 200mg/kg being most beneficial.

Original languageEnglish
Pages (from-to)68-71
Number of pages4
JournalPharmacognosy Journal
Volume6
Issue number4
DOIs
Publication statusPublished - 01-01-2014

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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