Effects of the whole plant extract (WPE), aqueous extract (AE), butanol fraction (BF) and petroleum ether fraction (PEF) of Tridax procumbens on dead space wound healing were studied in albino rats. Granuloma tissue harvested from 10 day old wounds was used for estimation of lysyl oxidase activity, tensile strength and other biochemical parameters. Lysyl oxidase activity, protein and nucleic acid contents as well as the tensile strength were all increased significantly in animals treated with WPE and AE. On the other hand, BF- and PEF-treated animals showed a decrease in all these parameters except tensile strength. In these two groups the hexosamine levels were increased (p < 0.001). Overall, WPE seems more active as compared to the other extracts.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Pharmaceutical Science
- Complementary and alternative medicine
- Molecular Medicine