Effect of vanillin on lipid profile in a model of hyperlipidemia, a preliminary study

Yogesh Belagali, Sheetal D. Ullal, Ahsan Shoeb, Vani Bhagwath, K. Ramya, Rakshitha Maskeri

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Abstract

To evaluate the effect of vanillin on the lipid profile of high fat diet induced hyperlipidemia in rats, the hyperlipidemia was induced by feeding cholesterol-rich high fat diet for 45 days in wistar rats of either sex. The reduction in the triglycerides and VLDL-C was significant at 200 & 400 mg/kg dose of vanillin compared to atorvastatin group. Reduction in total cholesterol was significant at 200 and 400 mg/kg doses compared to hyperlipidemic control. The results demonstrate that vanillin at a dose of 200 and 400 mg/kg body weight lowers the serum triglyceride, VLDL-C and total cholesterol level significantly in high fat diet induced hyperlipidemic rats. However there was no significant effect on the lipid profile at 100 mg/kg dose. There were no statistically significant changes in the HDL-C and LDL-C levels at any of the given doses.

Original languageEnglish
Pages (from-to)288-291
Number of pages4
JournalIndian Journal of Experimental Biology
Volume51
Issue number4
Publication statusPublished - 01-04-2013

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology
  • Cell Biology

Cite this

Belagali, Y., Ullal, S. D., Shoeb, A., Bhagwath, V., Ramya, K., & Maskeri, R. (2013). Effect of vanillin on lipid profile in a model of hyperlipidemia, a preliminary study. Indian Journal of Experimental Biology, 51(4), 288-291.