Effect of vitamin A compounds on DNA biosynthesis in murine tumor models in vitro

K. Satyamoorthy, M. P. Chitnis

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    Abstract

    The effect of vitamin A compounds on the DNA biosynthesis inhibition of murine ascites tumor models such as P388 lymphocytic leukemia, L1210 lymphoid leukemia, sarcoma 180 and Ehrlich ascites carcinoma was found to be concentration- and time-dependent. The results of the experiments carried out in vitro for 4 h measured by the extent of 3H-thymidine incorporation into the DNA of these tumor cells permit us to conclude that (a) at the given concentration and time, the metabolic role of vitamin A compounds influences the regulation of processes leading to DNA biosynthesis inhibition; (b) the effect of vitamin A is uniform irrespective of tumor cells heterogeneity; (c) vitamin A does not affect transport of thymidine, and (d) the dose-dependent increase in the inhibition of these tumor cells by vitamin A is characterized by undifferentiated morphology showing uniformity in the given tumor cell population associated with a total lack of differentiation.

    Original languageEnglish
    Pages (from-to)356-359
    Number of pages4
    JournalOncology
    Volume44
    Issue number6
    Publication statusPublished - 1987

    Fingerprint

    Vitamin A
    DNA
    Lymphoid Leukemia
    Neoplasms
    Ascites
    Thymidine
    Sarcoma 180
    Leukemia L1210
    In Vitro Techniques
    Carcinoma
    Population

    All Science Journal Classification (ASJC) codes

    • Cancer Research
    • Oncology

    Cite this

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    abstract = "The effect of vitamin A compounds on the DNA biosynthesis inhibition of murine ascites tumor models such as P388 lymphocytic leukemia, L1210 lymphoid leukemia, sarcoma 180 and Ehrlich ascites carcinoma was found to be concentration- and time-dependent. The results of the experiments carried out in vitro for 4 h measured by the extent of 3H-thymidine incorporation into the DNA of these tumor cells permit us to conclude that (a) at the given concentration and time, the metabolic role of vitamin A compounds influences the regulation of processes leading to DNA biosynthesis inhibition; (b) the effect of vitamin A is uniform irrespective of tumor cells heterogeneity; (c) vitamin A does not affect transport of thymidine, and (d) the dose-dependent increase in the inhibition of these tumor cells by vitamin A is characterized by undifferentiated morphology showing uniformity in the given tumor cell population associated with a total lack of differentiation.",
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    Effect of vitamin A compounds on DNA biosynthesis in murine tumor models in vitro. / Satyamoorthy, K.; Chitnis, M. P.

    In: Oncology, Vol. 44, No. 6, 1987, p. 356-359.

    Research output: Contribution to journalArticle

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