Effect of withaferin, a radiosensitizer, on the erythrocyte antioxidants in carcinoma of uterine cervix

Kumarchandra Reshma, A. V. Rao, M. Dinesh, D. M. Vasudevan

Research output: Contribution to journalArticle

Abstract

Withaferin, an active component obtained from the root extracts of Withania somnifera (Ashwaganda), showed antitumor and radiosensitising effects in animals. A similar approach in human cancer patients could probably increase the therapeutic outcome. Antioxidants are good markers of free radical induced tissue damage or in other words, radiosensitisation of tumor cells. Therefore an assay of erythrocyte antioxidant levels namely GSH, GSH-PX,SOD and G6PD were performed in cancers of uterine cervix, before, in the midst of, and post radiation and compared with the erythrocyte levels of the same in normal controls. Although a high level of GSH was observed in the baseline samples, this level was consistent after treatment. A significant decrease in GSHPX values following radiation was observed. SOD and G6PD levels remained non significant. Therefore establishing the role of withaferin as a radiosensitiser seems to be ambiguous.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalBiomedical Research
Volume18
Issue number3
Publication statusPublished - 01-09-2007

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Cervix Uteri
Antioxidants
Erythrocytes
Withania
Radiation
Radiation-Sensitizing Agents
Carcinoma
Uterine Cervical Neoplasms
Free Radicals
Tumors
Assays
Neoplasms
Animals
Cells
Tissue
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "Withaferin, an active component obtained from the root extracts of Withania somnifera (Ashwaganda), showed antitumor and radiosensitising effects in animals. A similar approach in human cancer patients could probably increase the therapeutic outcome. Antioxidants are good markers of free radical induced tissue damage or in other words, radiosensitisation of tumor cells. Therefore an assay of erythrocyte antioxidant levels namely GSH, GSH-PX,SOD and G6PD were performed in cancers of uterine cervix, before, in the midst of, and post radiation and compared with the erythrocyte levels of the same in normal controls. Although a high level of GSH was observed in the baseline samples, this level was consistent after treatment. A significant decrease in GSHPX values following radiation was observed. SOD and G6PD levels remained non significant. Therefore establishing the role of withaferin as a radiosensitiser seems to be ambiguous.",
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Effect of withaferin, a radiosensitizer, on the erythrocyte antioxidants in carcinoma of uterine cervix. / Reshma, Kumarchandra; Rao, A. V.; Dinesh, M.; Vasudevan, D. M.

In: Biomedical Research, Vol. 18, No. 3, 01.09.2007, p. 175-178.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of withaferin, a radiosensitizer, on the erythrocyte antioxidants in carcinoma of uterine cervix

AU - Reshma, Kumarchandra

AU - Rao, A. V.

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