Effect of withaferin, a radiosensitizer, on the erythrocyte antioxidants in carcinoma of uterine cervix

Kumarchandra Reshma; A. V. Rao; M. Dinesh; D. M. Vasudevan

Effect of withaferin, a radiosensitizer, on the erythrocyte antioxidants in carcinoma of uterine cervix

Kumarchandra Reshma, A. V. Rao, M. Dinesh, D. M. Vasudevan

Research output: Contribution to journal › Article › peer-review

Abstract

Withaferin, an active component obtained from the root extracts of Withania somnifera (Ashwaganda), showed antitumor and radiosensitising effects in animals. A similar approach in human cancer patients could probably increase the therapeutic outcome. Antioxidants are good markers of free radical induced tissue damage or in other words, radiosensitisation of tumor cells. Therefore an assay of erythrocyte antioxidant levels namely GSH, GSH-PX,SOD and G6PD were performed in cancers of uterine cervix, before, in the midst of, and post radiation and compared with the erythrocyte levels of the same in normal controls. Although a high level of GSH was observed in the baseline samples, this level was consistent after treatment. A significant decrease in GSHPX values following radiation was observed. SOD and G6PD levels remained non significant. Therefore establishing the role of withaferin as a radiosensitiser seems to be ambiguous.

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	Biomedical Research
Volume	18
Issue number	3
Publication status	Published - 01-09-2007

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Effect of withaferin, a radiosensitizer, on the erythrocyte antioxidants in carcinoma of uterine cervix",

abstract = "Withaferin, an active component obtained from the root extracts of Withania somnifera (Ashwaganda), showed antitumor and radiosensitising effects in animals. A similar approach in human cancer patients could probably increase the therapeutic outcome. Antioxidants are good markers of free radical induced tissue damage or in other words, radiosensitisation of tumor cells. Therefore an assay of erythrocyte antioxidant levels namely GSH, GSH-PX,SOD and G6PD were performed in cancers of uterine cervix, before, in the midst of, and post radiation and compared with the erythrocyte levels of the same in normal controls. Although a high level of GSH was observed in the baseline samples, this level was consistent after treatment. A significant decrease in GSHPX values following radiation was observed. SOD and G6PD levels remained non significant. Therefore establishing the role of withaferin as a radiosensitiser seems to be ambiguous.",

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T1 - Effect of withaferin, a radiosensitizer, on the erythrocyte antioxidants in carcinoma of uterine cervix

AU - Reshma, Kumarchandra

AU - Rao, A. V.

AU - Dinesh, M.

AU - Vasudevan, D. M.

PY - 2007/9/1

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N2 - Withaferin, an active component obtained from the root extracts of Withania somnifera (Ashwaganda), showed antitumor and radiosensitising effects in animals. A similar approach in human cancer patients could probably increase the therapeutic outcome. Antioxidants are good markers of free radical induced tissue damage or in other words, radiosensitisation of tumor cells. Therefore an assay of erythrocyte antioxidant levels namely GSH, GSH-PX,SOD and G6PD were performed in cancers of uterine cervix, before, in the midst of, and post radiation and compared with the erythrocyte levels of the same in normal controls. Although a high level of GSH was observed in the baseline samples, this level was consistent after treatment. A significant decrease in GSHPX values following radiation was observed. SOD and G6PD levels remained non significant. Therefore establishing the role of withaferin as a radiosensitiser seems to be ambiguous.

AB - Withaferin, an active component obtained from the root extracts of Withania somnifera (Ashwaganda), showed antitumor and radiosensitising effects in animals. A similar approach in human cancer patients could probably increase the therapeutic outcome. Antioxidants are good markers of free radical induced tissue damage or in other words, radiosensitisation of tumor cells. Therefore an assay of erythrocyte antioxidant levels namely GSH, GSH-PX,SOD and G6PD were performed in cancers of uterine cervix, before, in the midst of, and post radiation and compared with the erythrocyte levels of the same in normal controls. Although a high level of GSH was observed in the baseline samples, this level was consistent after treatment. A significant decrease in GSHPX values following radiation was observed. SOD and G6PD levels remained non significant. Therefore establishing the role of withaferin as a radiosensitiser seems to be ambiguous.

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Effect of withaferin, a radiosensitizer, on the erythrocyte antioxidants in carcinoma of uterine cervix

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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