Effects of captopril and losartan on thermal and chemical induced pain in mice

Rohit, U. S. Chakradhar Rao, H. N. Gopala Krishna

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers antagonists (ARAs) are widely used compounds in various cardiovascular disorders. ACEIs, but not ARAs, inhibit the enzyme dipeptidyl carboxypeptidase which is involved in the conversion of angiotensin I to II and degradation of kinins like bradykinin and substance P. Bradykinin and substance P are potent mediators of inflammation and pain. Hence the study was undertaken to evaluate the effects of captopril (an ACEI) and losartan (an ARA-AT1 receptor antagonist) on thermal and chemical induced nocioception by employing hot plate and acetic acid induced writhing tests respectively in mice. Inbred albino mice weighing between 25-30 g were used and they were divided into two sets, each set containing 7 groups. Control groups received normal saline and the remaining six groups received three doses (0.5, 1 and 2 mg/kg) of captopril and three doses (0.5, 1 and 2 mg/kg) of losartan. Drugs were administered intraperitoneally fifteen minutes before placing the animal over the hot plate or 30 minutes before injecting 0.6% acetic acid. Both drugs dose dependently reduced the reaction time in hot plate method. In chemical induced writhing test, both the drugs reduced the latency of onset of writhing and in captopril pretreated groups, acetic acid induced sustained abdominal contraction without any intermittent relaxation. However, in losartan pretreated animals acetic acid just increased the number of writhings without sustained abdominal contraction. Thus, our study suggests that both drugs have hyperalgesic effects.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalIndian Journal of Physiology and Pharmacology
Volume50
Issue number2
Publication statusPublished - 01-04-2006
Externally publishedYes

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Losartan
Angiotensin Receptor Antagonists
Captopril
Hot Temperature
Pain
Acetic Acid
Angiotensin-Converting Enzyme Inhibitors
Bradykinin
Substance P
Pharmaceutical Preparations
Inflammation Mediators
Angiotensin I
Kinins
Reaction Time
Control Groups
Enzymes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

Cite this

Rohit, Chakradhar Rao, U. S., & Gopala Krishna, H. N. (2006). Effects of captopril and losartan on thermal and chemical induced pain in mice. Indian Journal of Physiology and Pharmacology, 50(2), 169-174.
Rohit ; Chakradhar Rao, U. S. ; Gopala Krishna, H. N. / Effects of captopril and losartan on thermal and chemical induced pain in mice. In: Indian Journal of Physiology and Pharmacology. 2006 ; Vol. 50, No. 2. pp. 169-174.
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Rohit, Chakradhar Rao, US & Gopala Krishna, HN 2006, 'Effects of captopril and losartan on thermal and chemical induced pain in mice', Indian Journal of Physiology and Pharmacology, vol. 50, no. 2, pp. 169-174.

Effects of captopril and losartan on thermal and chemical induced pain in mice. / Rohit; Chakradhar Rao, U. S.; Gopala Krishna, H. N.

In: Indian Journal of Physiology and Pharmacology, Vol. 50, No. 2, 01.04.2006, p. 169-174.

Research output: Contribution to journalArticle

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