Effects of chronic prenatal restraint stress on anxiety in post weaned male and female wistar rats

Saju Binu Cherian, K. L. Bairy, Muddanna S. Rao, S. N. Somayaji, K. Ramnarayan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affect brain function of offspring when they are adult remains primarily unknown. Controversies exist in literature regarding sexual dimorphism in the effects of prenatal stress on the postnatal cognitive behavioral development. To investigate the effect of prenatal stress on locomotor, exploratory and emotional development, pregnant rats of Wistar strain were subjected to restraint stress from E11 till delivery. Male and female pups born to these stressed rats were subjected to open field test on 21st day of postnatal life. Results were compared with rats of the same age and sex born to control mothers, which were not stressed. The results showed that prenatal maternal restraint stress affected both male and female offsprings during young age. These results suggests that prolonged maternal stress leads to long lasting malfunction of the hippocampus, which extends to and is manifested in adulthood. Prenatally stressed males exhibited higher anxiety levels when compared to the stressed females suggesting that prenatal stress effects are gender- specific.

Original languageEnglish
Pages (from-to)99-122
Number of pages24
JournalPharmacologyonline
Volume2
Publication statusPublished - 06-10-2010
Externally publishedYes

Fingerprint

Wistar Rats
Anxiety
Mothers
Sex Characteristics
Hippocampus
Brain

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Cherian, S. B., Bairy, K. L., Rao, M. S., Somayaji, S. N., & Ramnarayan, K. (2010). Effects of chronic prenatal restraint stress on anxiety in post weaned male and female wistar rats. Pharmacologyonline, 2, 99-122.
Cherian, Saju Binu ; Bairy, K. L. ; Rao, Muddanna S. ; Somayaji, S. N. ; Ramnarayan, K. / Effects of chronic prenatal restraint stress on anxiety in post weaned male and female wistar rats. In: Pharmacologyonline. 2010 ; Vol. 2. pp. 99-122.
@article{9d9fde7887554267b943aaf04d70a2ad,
title = "Effects of chronic prenatal restraint stress on anxiety in post weaned male and female wistar rats",
abstract = "Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affect brain function of offspring when they are adult remains primarily unknown. Controversies exist in literature regarding sexual dimorphism in the effects of prenatal stress on the postnatal cognitive behavioral development. To investigate the effect of prenatal stress on locomotor, exploratory and emotional development, pregnant rats of Wistar strain were subjected to restraint stress from E11 till delivery. Male and female pups born to these stressed rats were subjected to open field test on 21st day of postnatal life. Results were compared with rats of the same age and sex born to control mothers, which were not stressed. The results showed that prenatal maternal restraint stress affected both male and female offsprings during young age. These results suggests that prolonged maternal stress leads to long lasting malfunction of the hippocampus, which extends to and is manifested in adulthood. Prenatally stressed males exhibited higher anxiety levels when compared to the stressed females suggesting that prenatal stress effects are gender- specific.",
author = "Cherian, {Saju Binu} and Bairy, {K. L.} and Rao, {Muddanna S.} and Somayaji, {S. N.} and K. Ramnarayan",
year = "2010",
month = "10",
day = "6",
language = "English",
volume = "2",
pages = "99--122",
journal = "Pharmacologyonline",
issn = "1827-8620",
publisher = "SILAE (Italo-Latin American Society of Ethnomedicine)",

}

Cherian, SB, Bairy, KL, Rao, MS, Somayaji, SN & Ramnarayan, K 2010, 'Effects of chronic prenatal restraint stress on anxiety in post weaned male and female wistar rats', Pharmacologyonline, vol. 2, pp. 99-122.

Effects of chronic prenatal restraint stress on anxiety in post weaned male and female wistar rats. / Cherian, Saju Binu; Bairy, K. L.; Rao, Muddanna S.; Somayaji, S. N.; Ramnarayan, K.

In: Pharmacologyonline, Vol. 2, 06.10.2010, p. 99-122.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of chronic prenatal restraint stress on anxiety in post weaned male and female wistar rats

AU - Cherian, Saju Binu

AU - Bairy, K. L.

AU - Rao, Muddanna S.

AU - Somayaji, S. N.

AU - Ramnarayan, K.

PY - 2010/10/6

Y1 - 2010/10/6

N2 - Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affect brain function of offspring when they are adult remains primarily unknown. Controversies exist in literature regarding sexual dimorphism in the effects of prenatal stress on the postnatal cognitive behavioral development. To investigate the effect of prenatal stress on locomotor, exploratory and emotional development, pregnant rats of Wistar strain were subjected to restraint stress from E11 till delivery. Male and female pups born to these stressed rats were subjected to open field test on 21st day of postnatal life. Results were compared with rats of the same age and sex born to control mothers, which were not stressed. The results showed that prenatal maternal restraint stress affected both male and female offsprings during young age. These results suggests that prolonged maternal stress leads to long lasting malfunction of the hippocampus, which extends to and is manifested in adulthood. Prenatally stressed males exhibited higher anxiety levels when compared to the stressed females suggesting that prenatal stress effects are gender- specific.

AB - Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affect brain function of offspring when they are adult remains primarily unknown. Controversies exist in literature regarding sexual dimorphism in the effects of prenatal stress on the postnatal cognitive behavioral development. To investigate the effect of prenatal stress on locomotor, exploratory and emotional development, pregnant rats of Wistar strain were subjected to restraint stress from E11 till delivery. Male and female pups born to these stressed rats were subjected to open field test on 21st day of postnatal life. Results were compared with rats of the same age and sex born to control mothers, which were not stressed. The results showed that prenatal maternal restraint stress affected both male and female offsprings during young age. These results suggests that prolonged maternal stress leads to long lasting malfunction of the hippocampus, which extends to and is manifested in adulthood. Prenatally stressed males exhibited higher anxiety levels when compared to the stressed females suggesting that prenatal stress effects are gender- specific.

UR - http://www.scopus.com/inward/record.url?scp=77957272622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957272622&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 99

EP - 122

JO - Pharmacologyonline

JF - Pharmacologyonline

SN - 1827-8620

ER -

Cherian SB, Bairy KL, Rao MS, Somayaji SN, Ramnarayan K. Effects of chronic prenatal restraint stress on anxiety in post weaned male and female wistar rats. Pharmacologyonline. 2010 Oct 6;2:99-122.