Effects of clonidine premedication on hemodynamic changes during laparoscopic cholecystectomy-A randomized control study

M. M. Chandrashekaraiah, M. Upadya, S. P. Jayachandran, M. Wali

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Purpose: Laparoscopic cholecystectomy is the treatment of choice for cholelithiasis. The pneumoperitoneum used for laparoscopic procedures leads to significant impairment of cardiopulmonary function. Methods: This randomized double blind study started with institute ethics committee approval. Sixty ASA 1 and ASA 2 patients undergoing elective laparoscopic cholecystectomy with no cardiovascular co-morbidity were enrolled for the study and received either tab clonidine 150 mcg [group C-30] or placebo drug tab lorazepam 2mg [group L30] orally one hour before the induction. Heart rate, systolic blood pressure, diastolic pressure and mean arterial pressure were recorded. The data obtained was analyzed using student's-test, ANOVA and Chi-square test. Results: There is significant reduction of heart rate (16.6003), systolic pressure (22.433) and mean arterial pressure (14.8) (p<0.001) in study group. Conclusion: From our study we found that oral clonidine 150mcg can effectively counteract the cardiovascular changes induced by pneumoperitoneum.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalApplied Cardiopulmonary Pathophysiology
Issue number3
Publication statusPublished - 01-12-2011


All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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